Under the background of building smart city and safe city,the new characteristics, new changes,new problems and new challenges emerge in an endless stream of comprehensive disaster prevention and reduction. Global climate change leads to a sharp increase in global environmental risks. Both the main characteristics of the risks from the natural disasters in China and the relevant status quo and features of the comprehensive disaster prevention and mitigation are systematically summarized herein,in which the development trend of the comprehensive disaster prevention and mitigation is fully combed and the three challenges faced by the comprehensive disaster prevention and mitigation are analyzed as well,thus five major pertinent and applicable strategy countermeasures are put forward. On one hand, the climate warming trend is to be intensified in China in the next 100 years, i. e. the frequencyofextremeweatherevents are to be increased,the trends of desertification,sea-level rise, glacier retreat are to be further aggravated,moreover,the suddenness,group-occurring character,abnormality of all kinds of catastrophicdisasters and all kinds of natural disasters triggered by them are gradually prominent. On the other hand,following with the economic development in China, both the energy consumption and the carbon dioxide emission are to be continuously increased, while the higher requirements are put forward by the economic development in China on the energy security, food security and ecologic security. In order to deal with all kinds of the adverse impacts from all kinds of disasters,the relevant monitoring and early warning level must be enhanced and comprehensive disaster prevention and mitigation system must be established in China, so as to fully improve the emergency capacity to deal with sudden disaster and catastrophicdisaster for promoting the establishment of the paradigm of regional comprehensive disaster prevention and mitigation,and then systematically implement the green economic development strategy with energy-saving and emission-reduction, thus transform the economic development mode concerned.