Based on the monthly meteorological data from 49 stations in Yun-Gui area during the period from 1960 to 2014, the values of the standardized precipitation and evapotranspiration index at season and year scale were calculated. Meanwhile,the variation of drought was analyzed using the methods of the run-length analysis theory and empirical orthogonal function(EOF).The results show that:(1)The Yun-Gui area showed a trend of gradually dry,and a wettingto- drying climate change since the 21 st century.(2)Under the same drought the occurring probability will be different depending on different dry grade,the lower the dry grade,the greater its probability,and vice versa.For the same grade of drought,the longer the drought lasted,the lower of its probability.(3)The return period of drought in Yunnan is shorter than that in other area,and that at the junction of Yun-Gui area is the longest.(4)The first mode of EOF explains the consistent pattern of drought in whole Yun-Gui area,and the second mode of EOF reflects the drying(or wetting)pattern in Yunnan province and wetting(or drying)in Guizhou province,because of the terrain differences and that WuMeng mountain cuts off the Yun-Gui area.