Under the background of climate warming, we discussed the response relationship between the radial growth of Larix sibirica and the climatic factors at different elevation of the eastern Tianshan Mountains, and validated this relationship by using the redundant analysis method. Compared with the standard chronology, the residual chronology of different elevation has larger characteristic parameters, higher SNR and mean sensitivity, and more environmental information, which is better to represent the overall change of trees. At 2 160 m(L1), after the rapid warming of the chronology(after 1985), the correlation between the tree-ring width and the temperature was reducing significantly. At 2 430 m(L2), the chronology is less associated with precipitation and temperature in two periods. At 2 700 m(L3), the positive response of the chronology to precipitation and temperature from 1985-2013 was enhanced. The response of radial growth to monthly climatic factors is higher in November and December of the last year, and the correlation between temperature and tree-ring width index is higher in June and July of the current year. Climate warming reduces the radial growth of trees, which is more obvious in low elevation areas. At all elevation, the sensitivity of L.sibirica to climate warming is decreasing. The radial growth of the L.sibirica at high elevation is mainly affected by the temperature, while that at middle and low elevation area is mainly affected by precipitation and temperature.