Sanitary landfilling method was the main way to deal with municipal solid waste in China. On the basis of the theory and analysis framework of life cycle assessment, the life cycle analysis of municipal solid waste disposal in Nanchang sanitary landfill was conducted with the aid of eFootprint software in order to find out the outstanding environmental impacts and reasons of various treatment processes and propose targeted improvement. The results showed that the main environmental impact types of sanitary landfills were global warming (GWP), primary energy demand (PED), resource depletion-water (WU), acidification (AP), photochemical ozone formation (POFP), Ecotoxicity (ET), and freshwater eutrophication (FEP). The distribution of electricity surplus as a by-product contributed to the reduction of the potential value of various environmental impact indicators, among which, the most prominent was PED, followed by WU. The most prominent type of environmental impact in the collection and transportation process was POFP, followed by ET, PED, and FEP. The use of diesel transporters should be reduced and energy-saving environmentally friendly or clean energy vehicles should be used moderately in this process. The environmental pollution caused by the sanitary landfill process was the largest. The most prominent environmental problem in this process was AP, followed by GWP, PED, FEP and ET. The landfill gas collection efficiency should be increased by improving the process and clean energy should be used to reduce diesel use in this process. The surplus power generated by landfill gas achieved positive environmental benefits after energy recovery. The efficiency of landfill gas collection and combustion electricity production need to be enhanced in this process. The environmental impact of the leachate treatment process was relatively small, mainly represented by WU and FED. It was necessary to optimize the upgrading process while focusing on energy conservation, and to improve the existing drawbacks of the disposal process and remove hidden dangers.