Changes of hydro-meteorological factors in the source region of the Yangtze River are a global concern.Pervious research focused on the temporal and spatial variation characteristics in hydro-meteorological factors.Research on the relationships between hydrometeorological factors and large-scale circulation in the source region of the Yangtze River is scarce.Based on the hydro-meteorological factors and large-scale atmospheric circulation factors in the source region of the Yangtze River,trends,volatilities and periodic changes of hydro-meteorology factors (precipitation,evapotranspiration and streamflow) during 1957-2012 were explored by using Mann-Kendall method,detrended fluctuation analysis method and wavelet analysis method.The relationships between hydro-meteorological factors and largescale atmospheric circulation factors were further studied.Meanwhile,the driving mechanism of large-scale atmospheric circulation on hydro-meteorological factors was disclosed by analyzing the water vapor flux in the source region of the Yangtze River.The results showed that climatic situations in the source region of the Yangtze River were basically characterized by warm and dry during 1990s.Since 2000s,the climatic turned to warm and wet.Time series of hydrometeorological factors in the source region of the Yangtze River had positive long-rang correlations.Climatic situation in the source region of the Yangtze River will keep warm and wet in the future.There were 1-5 year,10-24 year and 25-45 year periods of hydrometeorological factors in the source region of the Yangtze River.South Asian monsoon (SAM) is a relative important large-scale atmospheric circulation that can influence the precipitation and streamflow in the source region of the Yangtze River.It is mainly because the southwest vapor fluxes driven by the SAM are dominant source of vapor fluxes in the source region of the Yangtze River.