The response of tree radial growth and its sensitivity to climate change is an important topic in the global environmental research community.Using tree- ring width index data from 1058 sample sites in the United States and instrumental temperature and precipitation data since the 20th century,correlation analysis was carried out to reveal the spatiotemporal variation of tree radial growth's response and its sensitivity to climate changes.Results show that in the United States radial growth rates of trees were mostly negative correlated with temperature and positive correlated with precipitation.Moisture may be dominant limiting factor of tree growth in most of regions of the United States.Response sensitivity of tree radial growth rate to temperature and precipitation changes exhibited seasonal variations.The most sensitive season varies with regions.The spatial variability of most sensitive seasons was mainly resulted from seasonal variations of moisture conditions due to local seasonal cycles of temperature and precipitation.Moreover,the response sensitivities of tree radial growth rate to temperature and precipitation changes along with climate changes.The negative correlation between tree radial growth rate with temperature would be strengthened (weakened) along with the climate warming (cooling).The positive correlation between tree radial growth rate with precipitation would be strengthened (weakened) along with precipitation decrease (increase).