globalchange  > 气候变化与战略
DOI: 10.1016/j.envpol.2019.113840
Environmental temperature and human epigenetic modifications: A systematic review
Author: Xu R.; Li S.; Guo S.; Zhao Q.; Abramson M.J.; Li S.; Guo Y.
Source Publication: Environmental Pollution
ISSN: 2697491
Publishing Year: 2020
Volume: 259
Language: 英语
Keyword: Climate change ; Epidemiology ; Epigenetics ; Systematic review ; Temperature
Scopus Keyword: Alkylation ; Blood ; Blood pressure ; DNA ; Epidemiology ; Methylation ; Temperature ; Cross-sectional study ; Environment temperature ; Environmental temperature ; Epidemiological studies ; Epigenetic modification ; Epigenetics ; Human dna methylations ; Systematic Review ; Climate change ; acclimation ; air temperature ; climate change ; DNA ; epidemiology ; genome ; health impact ; literature review ; methylation ; temperature effect ; climate change ; DNA methylation ; environmental exposure ; environmental factor ; environmental impact ; environmental temperature ; epidemiological monitoring ; epigenetics ; genetic association ; genome-wide association study ; health status ; high risk population ; human ; long term exposure ; Review ; systematic review ; temperature acclimatization
English Abstract: The knowledge about the effects of environmental temperature on human epigenome is a potential key to understand the health impacts of temperature and to guide acclimation under climate change. We performed a systematic review on the epidemiological studies that have evaluated the association between environmental temperature and human epigenetic modifications. We identified seven original articles on this topic published between 2009 and 2019, including six cohort studies and one cross-sectional study. They focused on DNA methylation in elderly people (blood sample) or infants (placenta sample), with sample size ranging from 306 to 1798. These studies were conducted in relatively low temperature setting (median/mean temperature: 0.8–13 °C), and linear models were used to evaluate temperature-DNA methylation association over short period (≤28 days). It has been reported that short-term ambient temperature could affect global human DNA methylation. A total of 15 candidate genes (ICAM-1, CRAT, F3, TLR-2, iNOS, ZKSCAN4, ZNF227, ZNF595, ZNF597, ZNF668, CACNA1H, AIRE, MYEOV2, NKX1-2 and CCDC15) with methylation status associated with ambient temperature have been identified. DNA methylation on ZKSCAN4, ICAM-1 partly mediated the effect of short-term cold temperature on high blood pressure and ICAM-1 protein (related to cardiovascular events), respectively. In summary, epidemiological evidence about the impacts of environment temperature on human epigenetics remains scarce and limited to short-term linear effect of cold temperature on DNA methylation in elderly people and infants. More studies are needed to broaden our understanding of temperature related epigenetic changes, especially under a changing climate. © 2019 Elsevier Ltd
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Affiliation: Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, United Kingdom; Centre for Community Child Health, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC 3052, Australia

Recommended Citation:
Xu R.,Li S.,Guo S.,et al. Environmental temperature and human epigenetic modifications: A systematic review[J]. Environmental Pollution,2020-01-01,259
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