DOI: 10.3390/ijerph17041185
论文题名: Assessing endogenous and exogenous hormone exposures and breast development in a migrant study of Bangladeshi and British girls
作者: Howland R.E. ; Deziel N.C. ; Bentley G.R. ; Booth M. ; Choudhury O.A. ; Hofmann J.N. ; Hoover R.N. ; Katki H.A. ; Trabert B. ; Fox S.D. ; Troisi R. ; Houghton L.C.
刊名: International Journal of Environmental Research and Public Health
ISSN: 16617827
出版年: 2020
卷: 17, 期: 4 语种: 英语
英文关键词: Adolescents
; BPA
; Cancer
; Environmental exposure
; Estrogen
; Migrant study
Scopus关键词: 4,4' isopropylidenediphenol
; bisphenol A glucuronide
; estrogen
; phenol derivative
; unclassified drug
; adolescence
; cancer
; hormone
; metabolite
; womens health
; adolescent
; age
; Article
; Bangladeshi
; birthplace
; breast development
; British citizen
; child
; clinical assessment tool
; confidence interval
; controlled study
; cross-sectional study
; environmental factor
; estrogen blood level
; estrogen metabolism
; exposure
; female
; geometric mean
; hazard ratio
; human
; interview
; linear regression analysis
; liquid chromatography-mass spectrometry
; metabolite
; migrant
; parent
; preschool child
; race difference
; school child
; self report
; statistical analysis
; Tanner stage
; United Kingdom
; urinalysis
; United Kingdom
英文摘要: Timing of breast development (or thelarche) and its endogenous and exogenous determinants may underlie global variation in breast cancer incidence. The study objectives were to characterize endogenous estrogen levels and bisphenol A (BPA) exposure using a migrant study of adolescent girls and test whether concentrations explained differences in thelarche by birthplace and growth environment. Estrogen metabolites (EM) and BPA-glucuronide (BPA-G) were quantified in urine spot samples using liquid chromatography tandem mass spectrometry (LC-MS/MS) from a cross-sectional study of Bangladeshi, first-and second-generation Bangladeshi migrants to the UK, and white British girls aged 5–16 years (n = 348). Thelarche status at the time of interview was self-reported and defined equivalent to Tanner Stage ≥2. We compared geometric means (and 95% confidence interval (CIs)) of EM and BPA-G using linear regression and assessed whether EM and BPA-G explained any of the association between exposure to the UK and the age at thelarche using hazard ratios and 95% confidence intervals. Average EM decreased with exposure to the UK, whereas BPA-G increased and was significantly higher among white British (0.007 ng/mL, 95% CI: 0.0024–0.0217) and second-generation British-Bangladeshi girls (0.009 ng/mL, 95% CI: 0.0040–0.0187) compared to Bangladeshi girls (0.002 ng/mL, 95% CI: 0.0018–0.0034). Two of four EM ratios (16-pathway/parent and parent/all pathways) were significantly associated with thelarche. The relationship between exposure to the UK and thelarche did not change appreciably after adding EM and BPA-G to the models. While BPA-G is often considered a ubiquitous exposure, our findings suggest it can vary based on birthplace and growth environment, with increasing levels for girls who were born in or moved to the UK. Our study did not provide statistically significant evidence that BPA-G or EM concentrations explained earlier thelarche among girls who were born or raised in the UK. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/159388
Appears in Collections: 气候变化与战略
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作者单位: Department of Epidemiology, Mailman School of Public Health, New York, NY 10032, United States; Yale School of Public Health, Yale University, New Haven, CT 06510, United States; Division of Cancer Epidemiology and Genetics, National Cancer Institute, BethsedaMD 20892, United States; Department of Anthropology, Durham University, Durham, DH13LE, United Kingdom; Faculty of Medical Sciences, Newcastle University, Newcastle, NE24HH, United Kingdom; Sylhet MAG Osmani Medical College, Sylhet, WV23JH, Bangladesh; Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States
Recommended Citation:
Howland R.E.,Deziel N.C.,Bentley G.R.,et al. Assessing endogenous and exogenous hormone exposures and breast development in a migrant study of Bangladeshi and British girls[J]. International Journal of Environmental Research and Public Health,2020-01-01,17(4)