DOI: 10.1016/j.envint.2019.105384
论文题名: Life cycle exposure to propiconazole reduces fecundity by disrupting the steroidogenic pathway and altering DNA methylation in zebrafish (Danio rerio)
作者: Teng M. ; Chen X. ; Wang C. ; Song M. ; Zhang J. ; Bi S. ; Wang C.
刊名: Environment International
ISSN: 1604120
出版年: 2020
卷: 135 语种: 英语
英文关键词: DNA methylation
; Endocrine disruption
; Offspring development
; Propiconazole
; Reproduction
Scopus关键词: Alkylation
; Aquatic ecosystems
; Aquatic organisms
; Cell proliferation
; Endocrinology
; Genes
; Methylation
; Steroid hormones
; DNA Methylation
; Endocrine disruption
; Offspring development
; Propiconazole
; Reproduction
; DNA
; propiconazole
; sex hormone
; unclassified drug
; vitellogenin
; vitellogenin 1
; vitellogenin 2
; cyprinid
; DNA
; endocrine disruptor
; fecundity
; fungicide
; growth response
; life cycle
; methylation
; pollution exposure
; reproduction
; steroid
; animal tissue
; Article
; chemometrics
; controlled study
; correlation coefficient
; DNA methylation
; down regulation
; embryo
; environmental exposure
; epigenetics
; gene expression regulation
; genetic transcription
; histone modification
; hormone release
; hypothalamus hypophysis gonad system
; life cycle
; lipid metabolism
; lipid peroxidation
; nonhuman
; oocyte development
; photoperiodicity
; polymerization
; principal component analysis
; priority journal
; spermatogenesis
; steroidogenesis
; teleost
; zebra fish
; Danio rerio
英文摘要: Propiconazole is fungicide widely used in agriculture, which may enter aquatic ecosystems and affect organisms. In this study, zebrafish (Danio rerio) were exposed to environmentally relevant levels of propiconazole throughout the life cycle, from embryo to sexually mature adults, and the effects on growth, reproduction, and offspring viability were investigated. To investigate the mechanisms of propiconazole action, the sex steroid hormones and the expression of genes related to the hypothalamus-pituitary-gonad-liver (HPGL) axis and DNA methylation were examined. Growth decreased in the parental zebrafish (F0) after exposure to propiconazole for 120 days. In males, increases in the levels of 17β-estradiol and vitellogenin were observed. The alterations in sex steroid hormones were regulated by the expression of genes involved with the HPGL axis. The decreases in fecundity and fertilization of the F0 was induced by the global DNA methylation, and then may result in the abnormal development of the F1. Therefore, propiconazole disrupted the steroidogenic pathway and caused changes in global DNA methylation that induced reproductive toxicity. © 2019 The Authors Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/159821
Appears in Collections: 气候变化与战略
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作者单位: College of Sciences, China Agricultural University, Beijing, 100193, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; Tai'an Academy of Agricultural Sciences, Taian, Shandong Province 271000, China; Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States
Recommended Citation:
Teng M.,Chen X.,Wang C.,et al. Life cycle exposure to propiconazole reduces fecundity by disrupting the steroidogenic pathway and altering DNA methylation in zebrafish (Danio rerio)[J]. Environment International,2020-01-01,135