globalchange  > 气候变化与战略
DOI: 10.3390/nu12020574
论文题名:
Gut–joint axis: The role of physical exercise on gut microbiota modulation in older people with osteoarthritis
作者: de Sire A.; de Sire R.; Petito V.; Masi L.; Cisari C.; Gasbarrini A.; Scaldaferri F.; Invernizzi M.
刊名: Nutrients
ISSN: 20726643
出版年: 2020
卷: 12, 期:2
语种: 英语
英文关键词: Diet ; Exercise ; Gastrointestinal microbiome ; Gut dysbiosis ; Gut microbiota ; Inflammaging ; Knee osteoarthritis ; Osteoarthritis ; Probiotics ; Rehabilitation
Scopus关键词: bile acid ; cytokine ; immunoglobulin enhancer binding protein ; interleukin 6 ; lipopolysaccharide ; metalloproteinase ; nutraceutical ; probiotic agent ; short chain fatty acid ; tumor necrosis factor ; adipose tissue ; aged ; aging ; Bacteroidetes ; biodiversity ; body mass ; diet ; dietary supplement ; dysbiosis ; exercise ; Firmicutes ; gastrointestinal disease ; homeostasis ; human ; hypertension ; immune response ; inflammation ; intestine flora ; knee osteoarthritis ; lipid diet ; metabolic syndrome X ; microbiome ; mucosal immunity ; muscle function ; muscle mass ; nutritional status ; obesity ; osteoarthritis ; oxidative stress ; pathogenesis ; physical performance ; Review ; risk factor ; skeletal muscle
英文摘要: Osteoarthritis (OA) is considered one of the most common joint disorders worldwide and its prevalence is constantly increasing due to the global longevity and changes in eating habits and lifestyle. In this context, the role of gut microbiota (GM) in the pathogenesis of OA is still unclear. Perturbation of GM biodiversity and function, defined as ‘gut dysbiosis’, might be involved in the development of inflammaging, one of the main risk factors of OA development. It is well known that physical exercise could play a key role in the prevention and treatment of several chronic diseases including OA, and it is recommended by several guidelines as a first line intervention. Several studies have shown that physical exercise could modulate GM composition, boosting intestinal mucosal immunity, increasing the Bacteroidetes–Firmicutes ratio, modifying the bile acid profile, and improving the production of short chain fatty acids. Moreover, it has been shown that low intensity exercise might reduce the risk of gastrointestinal diseases, confirming the hypothesis of a strict correlation between skeletal muscle and GM. However, up to date, there is still a lack of clinical trials focusing on this research field. Therefore, in this narrative, we aimed to summarize the state-of-the-art of the literature regarding the correlation between these conditions, supporting the hypothesis of a ‘gut–joint axis’ and highlighting the role of physical exercise combined with adequate diet and probiotic supplements in rebalancing microbial dysbiosis. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/159890
Appears in Collections:气候变化与战略

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作者单位: Physical and Rehabilitation Medicine, Department of Health Sciences, University of Eastern Piedmont “A. Avogadro”, Novara, 28100, Italy; Rehabilitation Unit, “Mons. L. Novarese” Hospital, Moncrivello, Vercelli 13040, Italy; Gastroenterology Unit, Department of Clinical Medicine and Surgery, School of Medicine “Federico II”, Naples, 80131, Italy; Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Rome, 00168, Italy; UOC Medicina Interna e Gastroenterologia, Area Gastroenterologia e Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, 00168, Italy; Physical Medicine and Rehabilitation Unit, University Hospital “Maggiore della Carità”, Novara, 28100, Italy

Recommended Citation:
de Sire A.,de Sire R.,Petito V.,et al. Gut–joint axis: The role of physical exercise on gut microbiota modulation in older people with osteoarthritis[J]. Nutrients,2020-01-01,12(2)
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