DOI: 10.3390/nu12020352
论文题名: Alteration of microbiome profile by d-allulose in amelioration of high-fat-diet-induced obesity in mice
作者: Han Y. ; Park H. ; Choi B.-R. ; Ji Y. ; Kwon E.-Y. ; Choi M.-S.
刊名: Nutrients
ISSN: 20726643
出版年: 2020
卷: 12, 期: 2 语种: 英语
英文关键词: D-allulose
; Metagenomics
; Microbiome
; Obesity
; Sugar substitute
Scopus关键词: apolipoprotein B
; carbon dioxide
; erythritol
; high density lipoprotein cholesterol
; leptin
; psicose
; resistin
; RNA 16S
; short chain fatty acid
; triacylglycerol
; animal experiment
; animal tissue
; Article
; bacterial microbiome
; bacterium
; body fat
; body weight
; caloric intake
; controlled study
; Coprococcus
; diet supplementation
; diet-induced obesity
; DNA extraction
; energy expenditure
; enzyme activity
; Erysipelotrichaceae
; gas chromatography
; gene sequence
; genetic analysis
; Lactobacillus
; lipid diet
; lipid fingerprinting
; male
; metagenomics
; microbial community
; microbiome
; microflora
; mouse
; nonhuman
; oxygen consumption
; Turicibacter
英文摘要: Recently, there has been a global shift in diet towards an increased intake of energy-dense foods that are high in sugars. D-allulose has received attention as a sugar substitute and has been reported as one of the anti-obesity food components; however, its correlation with the intestinal microbial community is not yet completely understood. Thirty-six C57BL/6J mice were divided in to four dietary groups and fed a normal diet (ND), a high-fat diet (HFD, 20% fat, 1% cholesterol, w/w), and a HFD with 5% erythritol (ERY) and D-allulose (ALL) supplement for 16 weeks. A pair-feeding approach was used so that all groups receiving the high-fat diet would have the same calorie intake. As a result, body weight and body fat mass in the ALL group were significantly decreased toward the level of the normal group with a simultaneous decrease in plasma leptin and resistin. Fecal short-chain fatty acid (SCFA) production analysis revealed that ALL induced elevated total SCFA production compared to the other groups. Also, ALL supplement induced the change in the microbial community that could be responsible for improving the obesity based on 16S rRNA gene sequence analysis, and ALL significantly increased the energy expenditure in Day(6a.m to 6pm). Taken together, our findings suggest that 5% dietary ALL led to an improvement in HFD-induced obesity by altering the microbiome community. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/159925
Appears in Collections: 气候变化与战略
There are no files associated with this item.
作者单位: Department of Food Science and Nutrition, Kyungpook National University, 1370 San-Kyuk Dong Puk-Ku, Daegu, 41566, South Korea; Center for Food and Nutritional Genomics Research, Kyungpook National University, 1370 San-Kyuk Dong Puk-Ku, Daegu, 41566, South Korea; Department of Advanced Green Energy and Environment, Handong Global University, Pohang, Gyeongbuk 37554, South Korea
Recommended Citation:
Han Y.,Park H.,Choi B.-R.,et al. Alteration of microbiome profile by d-allulose in amelioration of high-fat-diet-induced obesity in mice[J]. Nutrients,2020-01-01,12(2)