globalchange  > 气候变化与战略
DOI: 10.1073/pnas.0802432105
论文题名:
Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish
作者: Chen Z.; Cheng C.-H.C.; Zhang J.; Cao L.; Chen L.; Zhou L.; Jin Y.; Ye H.; Deng C.; Dai Z.; Xu Q.; Hu P.; Sun S.; Shen Y.; Chen L.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2008
卷: 105, 期:35
起始页码: 12944
结束页码: 12949
语种: 英语
英文关键词: Cold adaptation ; Comparative genomics ; Gene duplication ; Genome evolution ; Retrotransposon
Scopus关键词: complementary DNA ; DNA ; transcriptome ; animal tissue ; Antarctica ; article ; chorion ; cold acclimatization ; comparative genomic hybridization ; controlled study ; degradation ; DNA hybridization ; DNA probe ; evolutionary adaptation ; fish ; freezing ; gene duplication ; gene expression ; gene function ; gene sequence ; genetic analysis ; genomics ; innate immunity ; life history ; lipid metabolism ; molecular evolution ; multigene family ; nonhuman ; priority journal ; protein determination ; protein expression ; protein folding ; protein synthesis ; teleost ; temperature ; transcriptomics ; upregulation ; Animals ; Antarctic Regions ; Cold ; Evolution, Molecular ; Fishes ; Gene Duplication ; Gene Expression Profiling ; Genome ; Heat ; Molecular Sequence Data ; Seawater ; Tropical Climate ; Dissostichus mawsoni ; Pisces ; Teleostei
英文摘要: The antifreeze glycoprotein-fortified Antarctic notothenioid fishes comprise the predominant fish suborder in the isolated frigid Southern Ocean. Their ecological success undoubtedly entailed evolutionary acquisition of a full suite of cold-stable functions besides antifreeze protection. Prior studies of adaptive changes in these teleost fishes generally examined a single genotype or phenotype. We report here the genome-wide investigations of transcriptional and genomic changes associated with Antarctic notothenioid cold adaptation. We sequenced and characterized 33,560 ESTs from four tissues of the Antarctic notothenioid Dissostichus mawsoni and derived 3,114 nonredundant protein gene families and their expression profiles. Through comparative analyses of same-tissue transcriptome profiles of D. mawsoni and temperate/tropical teleost fishes, we identified 177 notothenioid protein families that were expressed many fold over the latter, indicating cold-related up-regulation. These up-regulated gene families operate in protein biosynthesis, protein folding and degradation, lipid metabolism, antioxidation, antiapoptosis, innate immunity, choriongenesis, and others, all of recognizable functional importance in mitigating stresses in freezing temperatures during notothenioid life histories. We further examined the genomic and evolutionary bases for this expressional up-regulation by comparative genomic hybridization of DNA from four pairs of Antarctic and basal non-Antarctic notothenioids to 10,700 D. mawsoni cDNA probes and discovered significant to astounding (3-to >300-fold, P < 0.05) Antarctic-specific duplications of 118 protein-coding genes, many of which correspond to the up-regulated gene families. Results of our integrative tripartite study strongly suggest that evolution under constant cold has resulted in dramatic genomic expansions of specific protein gene families, augmenting gene expression and gene functions contributing to physiological fitness of Antarctic notothenioids in freezing polar conditions. © 2008 by The National Academy of Sciences of the USA.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/162170
Appears in Collections:气候变化与战略

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作者单位: Chen, Z., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China; Cheng, C.-H.C., Department of Animal Biology, University of Illinois, 515 Morrill Hall, Urbana, IL 61801, United States; Zhang, J., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China; Cao, L., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China; Chen, L., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China; Zhou, L., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China; Jin, Y., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China; Ye, H., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China; Deng, C., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China; Dai, Z., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China; Xu, Q., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China; Hu, P., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China; Sun, S., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China; Shen, Y., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China; Chen, L., Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Beijing 100101, China

Recommended Citation:
Chen Z.,Cheng C.-H.C.,Zhang J.,et al. Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish[J]. Proceedings of the National Academy of Sciences of the United States of America,2008-01-01,105(35)
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