globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1513696112
论文题名:
Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments
作者: Librado P.; Der Sarkissian C.; Ermini L.; Schubert M.; Jónsson H.; Albrechtsen A.; Fumagalli M.; Yang M.A.; Gamba C.; Seguin-Orlando A.; Mortensen C.D.; Petersen B.; Hoove C.A.; Lorente-Galdos B.; Nedoluzhko A.; Boulygina E.; Tsygankova S.; Neuditschko M.; Jagannathan V.; Thèves C.; Alfarhan A.H.; Alquraishi S.A.; Al-Rasheid K.A.S.; Sicheritz-Ponten T.; Popov R.; Grigoriev S.; Alekseev A.N.; Rubin E.M.; McCue M.; Rieder S.; Leeb T.; Tikhonov A.; Crubézy E.; Slatkin M.; Marques-Bonet T.; Nielsen R.; Willerslev E.; Kantanen J.; Prokhortchouk E.; Orlando L.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2015
卷: 112, 期:50
起始页码: E6889
结束页码: E6897
语种: 英语
英文关键词: Adaptation ; Ancient genomics ; Horse ; Population discontinuity ; Regulatory changes
Scopus关键词: hormone ; mitochondrial DNA ; ribosome RNA ; transfer RNA ; animal experiment ; Article ; body size ; conformational transition ; controlled study ; convergent evolution ; environmental temperature ; evolutionary adaptation ; gene mutation ; gene sequence ; genetic variability ; genome analysis ; hair growth ; Holocene ; horse ; mammoth ; metabolic balance ; migration ; mitochondrial genome ; nonhuman ; phenotypic variation ; population ; priority journal ; Przewalski's horse ; regulatory mechanism ; seasonal variation ; signal transduction ; survival rate ; Upper Pleistocene ; Yakut (people) ; adaptation ; animal ; Arctic ; cold ; genetics ; genome ; horse ; molecular evolution ; physiology ; Russian Federation ; Adaptation, Physiological ; Animals ; Arctic Regions ; Cold Temperature ; Evolution, Molecular ; Genome ; Horses ; Siberia
英文摘要: Yakutia, Sakha Republic, in the Siberian Far East, represents one of the coldest places on Earth, with winter record temperatures dropping below-70 °C. Nevertheless, Yakutian horses survive all year round in the open air due to striking phenotypic adaptations, including compact body conformations, extremely hairy winter coats, and acute seasonal differences in metabolic activities. The evolutionary origins of Yakutian horses and the genetic basis of their adaptations remain, however, contentious. Here, we present the complete genomes of nine present-day Yakutian horses and two ancient specimens dating from the early 19th century and ∼5,200 y ago. By comparing these genomes with the genomes of two Late Pleistocene, 27 domesticated, and three wild Przewalski's horses, we find that contemporary Yakutian horses do not descend from the native horses that populated the region until the mid-Holocene, but were most likely introduced following the migration of the Yakut people a few centuries ago. Thus, they represent one of the fastest cases of adaptation to the extreme temperatures of the Arctic. We find cisregulatorymutations to have contributed more than nonsynonymous changes to their adaptation, likely due to the comparatively limited standing variation within gene bodies at the time the population was founded. Genes involved in hair development, body size, and metabolic and hormone signaling pathways represent an essential part of the Yakutian horse adaptive genetic toolkit. Finally, we find evidence for convergent evolution with native human populations and woolly mammoths, suggesting that only a few evolutionary strategies are compatible with survival in extremely cold environments.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/162203
Appears in Collections:气候变化与战略

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作者单位: Librado, P., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark; Der Sarkissian, C., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark; Ermini, L., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark; Schubert, M., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark; Jónsson, H., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark; Albrechtsen, A., Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, 2200N, Denmark; Fumagalli, M., UCL Genetics Institute, Department of Genetics, Evolution, and Environment, University College London, London, WC1E 6BT, United Kingdom; Yang, M.A., Department of Integrative Biology, University of California, Berkeley, CA 94720-3140, United States; Gamba, C., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark; Seguin-Orlando, A., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark, National High-Throughput DNA Sequencing Centre, University of Copenhagen, Copenhagen, 1353K, Denmark; Mortensen, C.D., National High-Throughput DNA Sequencing Centre, University of Copenhagen, Copenhagen, 1353K, Denmark; Petersen, B., Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, 2800, Denmark; Hoove, C.A., Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, United States; Lorente-Galdos, B., Universitat Pompeu Fabra/Consejo Superior de Investigaciones Cientificas, Barcelona, 08003, Spain, Centro Nacional de Análisis Genómico, Barcelona, 08028, Spain; Nedoluzhko, A., National Research Centre Kurchatov Institute, Moscow, 123182, Russian Federation; Boulygina, E., National Research Centre Kurchatov Institute, Moscow, 123182, Russian Federation; Tsygankova, S., National Research Centre Kurchatov Institute, Moscow, 123182, Russian Federation; Neuditschko, M., Agroscope, Swiss National Stud Farm, Avenches, 1580, Switzerland; Jagannathan, V., Institute of Genetics, University of Bern, Bern, 3001, Switzerland; Thèves, C., Université de Toulouse, University Paul Sabatier, Laboratoire d'Anthropobiologie Moléculaire et d'Imagerie de Synthèse, CNRS UMR 5288, Toulouse, 31000, France; Alfarhan, A.H., Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Alquraishi, S.A., Yakutian Research Institute of Agriculture, Yakutsk, Sakha, 677002, Russian Federation; Al-Rasheid, K.A.S., Yakutian Research Institute of Agriculture, Yakutsk, Sakha, 677002, Russian Federation; Sicheritz-Ponten, T., Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, 2800, Denmark; Popov, R., North-Eastern Federal University, Yakutsk, 677000, Russian Federation; Grigoriev, S., College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, United States; Alekseev, A.N., College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, United States; Rubin, E.M., Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, United States; McCue, M., Zoological Institute of Russian Academy of Sciences, Saint-Petersburg, 199034, Russian Federation; Rieder, S., Agroscope, Swiss National Stud Farm, Avenches, 1580, Switzerland; Leeb, T., Institute of Genetics, University of Bern, Bern, 3001, Switzerland; Tikhonov, A., Center for Theoretical Evolutionary Genomics, University of California, Berkeley, CA 94720-3140, United States; Crubézy, E., UCL Genetics Institute, Department of Genetics, Evolution, and Environment, University College London, London, WC1E 6BT, United Kingdom; Slatkin, M., Department of Integrative Biology, University of California, Berkeley, CA 94720-3140, United States; Marques-Bonet, T., Universitat Pompeu Fabra/Consejo Superior de Investigaciones Cientificas, Barcelona, 08003, Spain, Centro Nacional de Análisis Genómico, Barcelona, 08028, Spain; Nielsen, R., Biotechnology and Food Research, Agrifood Research Finland, Jokioinen, 31600, Finland; Willerslev, E., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark; Kantanen, J., Department of Biology, University of Eastern Finland, Kuopio, 70211, Finland; Prokhortchouk, E., National Research Centre Kurchatov Institute, Moscow, 123182, Russian Federation; Orlando, L., Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350K, Denmark, Université de Toulouse, University Paul Sabatier, Laboratoire d'Anthropobiologie Moléculaire et d'Imagerie de Synthèse, CNRS UMR 5288, Toulouse, 31000, France

Recommended Citation:
Librado P.,Der Sarkissian C.,Ermini L.,et al. Tracking the origins of Yakutian horses and the genetic basis for their fast adaptation to subarctic environments[J]. Proceedings of the National Academy of Sciences of the United States of America,2015-01-01,112(50)
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