globalchange  > 气候变化与战略
DOI: 10.1073/PNAS.2001114117
论文题名:
Revealing the origin of multiphasic dynamic behaviors in cyanobacteriochrome
作者: Wang D.; Li X.; Zhang S.; Wang L.; Yang X.; Zhong D.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期:33
起始页码: 19731
结束页码: 19736
语种: 英语
英文关键词: Active-site relaxation ; Conical intersection ; Double-bond twisting ; Femtosecond spectroscopy ; Site-directed mutation
Scopus关键词: phytochrome ; bacterial protein ; visual proteins and pigments ; absorption ; Article ; binding site ; controlled study ; cyanobacterium ; excitation ; fluorescence analysis ; hydrogen bond ; isomerization ; molecular dynamics ; nonhuman ; photoreceptor ; priority journal ; solvation ; steady state ; surface property ; chemistry ; cyanobacterium ; enzyme active site ; genetics ; isomerism ; kinetics ; metabolism ; Bacterial Proteins ; Catalytic Domain ; Cyanobacteria ; Isomerism ; Kinetics ; Photoreceptors, Microbial
英文摘要: Cyanobacteriochromes are photoreceptors in cyanobacteria that exhibit a wide spectral coverage and unique photophysical properties from the photoinduced isomerization of a linear tetrapyrrole chromophore. Here, we integrate femtosecond-resolved fluorescence and transient-absorption methods and unambiguously showed the significant solvation dynamics occurring at the active site from a few to hundreds of picoseconds. These motions of local water molecules and polar side chains are continuously convoluted with the isomerization reaction, leading to a nonequilibrium processes with continuous active-site motions. By mutations of critical residues at the active site, the modified local structures become looser, resulting in faster solvation relaxations and isomerization reaction. The observation of solvation dynamics is significant and critical to the correct interpretation of often-observed multiphasic dynamic behaviors, and thus the previously invoked ground-state heterogeneity may not be relevant to the excited-state isomerization reaction. © 2020 National Academy of Sciences. All rights reserved.
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被引频次[WOS]:9   [查看WOS记录]     [查看WOS中相关记录]
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163421
Appears in Collections:气候变化与战略

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作者单位: Wang, D., Department of Physics, Ohio State University, Columbus, OH 43210, United States, Program of Biochemistry, Ohio State University, Columbus, OH 43210, United States; Li, X., Department of Physics, Ohio State University, Columbus, OH 43210, United States, Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH 43210, United States; Zhang, S., Department of Physics, Ohio State University, Columbus, OH 43210, United States; Wang, L., Department of Physics, Ohio State University, Columbus, OH 43210, United States; Yang, X., Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, United States; Zhong, D., Department of Physics, Ohio State University, Columbus, OH 43210, United States, Program of Biochemistry, Ohio State University, Columbus, OH 43210, United States, Department of Chemistry and Biochemistry, Ohio State University, Columbus, OH 43210, United States, Program of Biophysics, Ohio State University, Columbus, OH 43210, United States, Program of Chemical Physics, Ohio State University, Columbus, OH 43210, United States

Recommended Citation:
Wang D.,Li X.,Zhang S.,et al. Revealing the origin of multiphasic dynamic behaviors in cyanobacteriochrome[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(33)
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