globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1818099116
论文题名:
Ionic stress enhances ER–PM connectivity via phosphoinositide-associated SYT1 contact site expansion in Arabidopsis
作者: Lee E.; Vanneste S.; Pérez-Sancho J.; Benitez-Fuente F.; Strelau M.; Macho A.P.; Botella M.A.; Friml J.; Rosado A.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2019
卷: 116, 期:4
起始页码: 1420
结束页码: 1429
语种: 英语
英文关键词: Cytoskeleton ; ER–PM contact sites ; Ionic stress ; Phosphoinositides ; SYT1
Scopus关键词: phosphatidylinositide ; phosphatidylinositol 4,5 bisphosphate ; synaptotagmin I ; Arabidopsis protein ; phosphatidylinositol ; phosphatidylinositol 4,5 bisphosphate ; synaptotagmin I ; SYT1 protein, Arabidopsis ; Arabidopsis thaliana ; Article ; cell expansion ; cell membrane ; cell membrane contact site ; controlled study ; cytoskeleton ; endoplasmic reticulum ; eukaryote ; ionic stress ; nonhuman ; plant stress ; priority journal ; signal transduction ; Arabidopsis ; cell membrane ; endoplasmic reticulum ; metabolism ; physiological stress ; physiology ; Arabidopsis ; Arabidopsis Proteins ; Cell Membrane ; Cytoskeleton ; Endoplasmic Reticulum ; Eukaryota ; Phosphatidylinositol 4,5-Diphosphate ; Phosphatidylinositols ; Stress, Physiological ; Synaptotagmin I
英文摘要: The interorganelle communication mediated by membrane contact sites (MCSs) is an evolutionary hallmark of eukaryotic cells. MCS connections enable the nonvesicular exchange of information between organelles and allow them to coordinate responses to changing cellular environments. In plants, the importance of MCS components in the responses to environmental stress has been widely established, but the molecular mechanisms regulating interorganelle connectivity during stress still remain opaque. In this report, we use the model plant Arabidopsis thaliana to show that ionic stress increases endoplasmic reticulum (ER)–plasma membrane (PM) connectivity by promoting the cortical expansion of synaptotagmin 1 (SYT1)-enriched ER–PM contact sites (S-EPCSs). We define differential roles for the cortical cytoskeleton in the regulation of S-EPCS dynamics and ER–PM connectivity, and we identify the accumulation of phosphatidylinositol 4,5-bisphos-phate [PI(4,5)P 2 ] at the PM as a molecular signal associated with the ER–PM connectivity changes. Our study highlights the functional conservation of EPCS components and PM phosphoinositides as modulators of ER–PM connectivity in eukaryotes, and uncovers unique aspects of the spatiotemporal regulation of ER–PM connectivity in plants. © 2019 National Academy of Sciences. All Rights Reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163574
Appears in Collections:气候变化与战略

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作者单位: Lee, E., Department of Botany, Faculty of Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Vanneste, S., Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, 9000, Belgium, Center for Plant Systems Biology, Vlaams Instituut voor Biotechnologie, Ghent, 9052, Belgium, Lab of Plant Growth Analysis, Ghent University Global Campus, Incheon, 21985, South Korea; Pérez-Sancho, J., Instituto de Hortofruticultura Subtropical y Mediterránea, Universidad de Málaga–Consejo Superior de Investigaciones Científicas, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, 29071, Spain, Shanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China; Benitez-Fuente, F., Department of Botany, Faculty of Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada, Instituto de Hortofruticultura Subtropical y Mediterránea, Universidad de Málaga-Consejo Superior de Investigaciones Científicas, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, 29071, Spain; Strelau, M., Department of Botany, Faculty of Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Macho, A.P., Shanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China; Botella, M.A., Instituto de Hortofruticultura Subtropical y Mediterránea, Universidad de Málaga–Consejo Superior de Investigaciones Científicas, Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Málaga, 29071, Spain; Friml, J., Institute of Science and Technology, Klosterneuburg, 3400, Austria; Rosado, A., Department of Botany, Faculty of Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada

Recommended Citation:
Lee E.,Vanneste S.,Pérez-Sancho J.,et al. Ionic stress enhances ER–PM connectivity via phosphoinositide-associated SYT1 contact site expansion in Arabidopsis[J]. Proceedings of the National Academy of Sciences of the United States of America,2019-01-01,116(4)
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