globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1820455116
论文题名:
Systematic mapping of cell wall mechanics in the regulation of cell morphogenesis
作者: Davì V.; Chevalier L.; Guo H.; Tanimoto H.; Barrett K.; Couturier E.; Boudaoud A.; Minc N.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2019
卷: 116, 期:28
起始页码: 13833
结束页码: 13838
语种: 英语
英文关键词: Cell shape ; Cell surface mechanics ; Cell wall ; Fission yeast
Scopus关键词: Article ; cell maturation ; cell size ; cell surface ; cell survival ; cell viability ; cell wall ; cellular parameters ; cladistics ; controlled study ; fungal strain ; imaging ; nonhuman ; priority journal ; quantitative analysis ; Schizosaccharomyces pombe ; biomechanics ; cell membrane ; cell wall ; chemistry ; growth, development and aging ; mechanical stress ; morphogenesis ; pressure ; Schizosaccharomyces ; surface property ; Young modulus ; actin ; Actins ; Biomechanical Phenomena ; Cell Membrane ; Cell Wall ; Elastic Modulus ; Morphogenesis ; Pressure ; Schizosaccharomyces ; Stress, Mechanical ; Surface Properties
英文摘要: Walled cells of plants, fungi, and bacteria come with a large range of shapes and sizes, which are ultimately dictated by the mechanics of their cell wall. This stiff and thin polymeric layer encases the plasma membrane and protects the cells mechanically by opposing large turgor pressure derived mechanical stresses. To date, however, we still lack a quantitative understanding for how local and/or global mechanical properties of the wall support cell morphogenesis. Here, we combine subresolution imaging and laser-mediated wall relaxation to quantitate subcellular values of wall thickness (h) and bulk elastic moduli (Y) in large populations of live mutant cells and in conditions affecting cell diameter in the rod-shaped model fission yeast. We find that lateral wall stiffness, defined by the surface modulus, σ = hY, robustly scales with cell diameter. This scaling is valid across tens of mutants spanning various functions—within the population of individual isogenic strains, along single misshaped cells, and even across the fission yeasts clade. Dynamic modulations of cell diameter by chemical and/or mechanical means suggest that the cell wall can rapidly adapt its surface mechanics, rendering stretched wall portions stiffer than unstretched ones. Size-dependent wall stiffening constrains diameter definition and limits size variations; it may also provide an efficient means to keep elastic strains in the wall below failure strains, potentially promoting cell survival. This quantitative set of data impacts our current understanding of the mechanics of cell walls and its contribution to morphogenesis. © 2019 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163590
Appears in Collections:气候变化与战略

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作者单位: Davì, V., Institut Jacques Monod, CNRS, Université de Paris, Paris Cedex 13, 75205, France; Chevalier, L., Institut Jacques Monod, CNRS, Université de Paris, Paris Cedex 13, 75205, France; Guo, H., Institut Jacques Monod, CNRS, Université de Paris, Paris Cedex 13, 75205, France, Center for Research and Interdisciplinarity, Université de Paris, Paris, 75004, France; Tanimoto, H., Institut Jacques Monod, CNRS, Université de Paris, Paris Cedex 13, 75205, France, Department of Materials Science, Yokohama City University, Yokohama, 236-0004, Japan; Barrett, K., Institut Jacques Monod, CNRS, Université de Paris, Paris Cedex 13, 75205, France; Couturier, E., Laboratoire Matières et Systèmes Complexes, UMR 7057, CNRS, Université de Paris, Paris Cedex 13, 75205, France; Boudaoud, A., Reproduction et Développement des Plantes, École Normale Supérieure de Lyon, Claude Bernard Lyon I, Inra, Université de Lyon, CNRS, Lyon Cedex 07, 69364, France; Minc, N., Institut Jacques Monod, CNRS, Université de Paris, Paris Cedex 13, 75205, France

Recommended Citation:
Davì V.,Chevalier L.,Guo H.,et al. Systematic mapping of cell wall mechanics in the regulation of cell morphogenesis[J]. Proceedings of the National Academy of Sciences of the United States of America,2019-01-01,116(28)
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