globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1902532116
论文题名:
Arabinogalactan protein–rare earth element complexes activate plant endocytosis
作者: Wang L.; Cheng M.; Yang Q.; Li J.; Wang X.; Zhou Q.; Nagawa S.; Xia B.; Xu T.; Huang R.; He J.; Li C.; Fu Y.; Liu Y.; Bao J.; Wei H.; Li H.; Tan L.; Gu Z.; Xia A.; Huang X.; Yang Z.; Deng X.W.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2019
卷: 116, 期:28
起始页码: 14349
结束页码: 14357
语种: 英语
英文关键词: Arabinogalactan proteins ; Endocytosis ; Extracellular cargo ; Lanthanum ; Superresolution imaging
Scopus关键词: adaptor protein ; adaptor protein 2 ; arabinogalactan protein ; glycoprotein ; lanthanide ; unclassified drug ; Arabidopsis ; Article ; cell surface ; cellular distribution ; clathrin mediated endocytosis ; complex formation ; controlled study ; endocytosis ; endosome ; HEK293 cell line ; human ; human cell ; immunogold labeling ; internalization ; isotope labeling ; nonhuman ; plant leaf ; priority journal ; protein protein interaction
英文摘要: Endocytosis is essential to all eukaryotes, but how cargoes are selected for internalization remains poorly characterized. Extracellular cargoes are thought to be selected by transmembrane receptors that bind intracellular adaptors proteins to initiate endocytosis. Here, we report a mechanism for clathrin-mediated endocytosis (CME) of extracellular lanthanum [La(III)] cargoes, which requires extracellular arabinogalactan proteins (AGPs) that are anchored on the outer face of the plasma membrane. AGPs were colocalized with La(III) on the cell surface and in La(III)induced endocytic vesicles in Arabidopsis leaf cells. Superresolution imaging showed that La(III) triggered AGP movement across the plasma membrane. AGPs were then colocalized and physically associated with the μ subunit of the intracellular adaptor protein 2 (AP2) complexes. The AGP-AP2 interaction was independent of CME, whereas AGP’s internalization required CME and AP2. Moreover, we show that AGP-dependent endocytosis in the presence of La(III) also occurred in human cells. These findings indicate that extracellular AGPs act as conserved CME cargo receptors, thus challenging the current paradigm about endocytosis of extracellular cargoes. © 2019 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163612
Appears in Collections:气候变化与战略

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作者单位: Wang, L., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China, State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China; Cheng, M., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Yang, Q., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Li, J., China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China; Wang, X., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Zhou, Q., State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China; Nagawa, S., Fujian Agriculture and Forestry University, University of California, Riverside Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China, Shanghai Center for Plant Stress Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China; Xia, B., State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China; Xu, T., Fujian Agriculture and Forestry University, University of California, Riverside Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China, Shanghai Center for Plant Stress Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China; Huang, R., Fujian Agriculture and Forestry University, University of California, Riverside Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China, Shanghai Center for Plant Stress Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China; He, J., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Li, C., China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China; Fu, Y., China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China; Liu, Y., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Bao, J., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Wei, H., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Li, H., Shanghai Center for Plant Stress Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China, School of Life Sciences, East China Normal University, Shanghai, 200241, China; Tan, L., Shanghai Center for Plant Stress Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China; Gu, Z., Shanghai Center for Plant Stress Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, 201602, China; Xia, A., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Huang, X., National and Local Joint Engineering, Research Center of Biomedical Functional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China; Yang, Z., Center for Plant Cell Biology, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, United States, Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, United States; Deng, X.W., State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, School of Advanced Agricultural Sciences, School of Life Sciences, Peking University, Beijing, 100871, China

Recommended Citation:
Wang L.,Cheng M.,Yang Q.,et al. Arabinogalactan protein–rare earth element complexes activate plant endocytosis[J]. Proceedings of the National Academy of Sciences of the United States of America,2019-01-01,116(28)
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