globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1802561115
论文题名:
Human exonization through differential nucleosome occupancy
作者: Li Y.; Li C.; Li S.; Peng Q.; An N.A.; He A.; Li C.-Y.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2018
卷: 115, 期:35
起始页码: 8817
结束页码: 8822
语种: 英语
英文关键词: Comparative genomics ; Exon origination ; Exonization ; Nucleosome occupancy ; Primate evolution
Scopus关键词: animal experiment ; article ; DNA base composition ; exon ; genome ; genomics ; intron ; Macaca ; mouse ; nonhuman ; nucleosome ; pig ; RNA sequence ; tissues ; Tupaiidae ; animal ; exon ; genetics ; genome-wide association study ; human ; Macaca ; metabolism ; molecular evolution ; nucleosome ; physiology ; Animals ; Base Composition ; Evolution, Molecular ; Exons ; Genome-Wide Association Study ; Humans ; Introns ; Macaca ; Mice ; Nucleosomes
英文摘要: Nucleosomal modifications have been implicated in fundamental epigenetic regulation, but the roles of nucleosome occupancy in shaping changes through evolution remain to be addressed. Here we present high-resolution nucleosome occupancy profiles for multiple tissues derived from human, macaque, tree shrew, mouse, and pig. Genome-wide comparison reveals conserved nucleosome occupancy profiles across both different species and tissue types. Notably, we found significantly higher levels of nucleosome occupancy in exons than in introns, a pattern correlated with the different exon–intron GC content. We then determined whether this biased occupancy may play roles in the origination of new exons through evolution, rather than being a downstream effect of exonization, through a comparative approach to sequentially trace the order of the exonization and biased nucleosome binding. By identifying recently evolved exons in human but not in macaque using matched RNA sequencing, we found that higher exonic nucleosome occupancy also existed in macaque regions orthologous to these exons. Presumably, such biased nucleosome occupancy facilitates the origination of new exons by increasing the splice strength of the ancestral nonexonic regions through driving a local difference in GC content. These data thus support a model that sites bound by nucleosomes are more likely to evolve into exons, which we term the “nucleosome-first” model. © National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163671
Appears in Collections:气候变化与战略

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作者单位: Li, Y., Institute of Molecular Medicine, Peking University, Beijing, 100871, China, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, 100871, China; Li, C., Institute of Molecular Medicine, Peking University, Beijing, 100871, China, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, 100871, China; Li, S., Institute of Molecular Medicine, Peking University, Beijing, 100871, China, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, 100871, China; Peng, Q., Institute of Molecular Medicine, Peking University, Beijing, 100871, China, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, 100871, China; An, N.A., Institute of Molecular Medicine, Peking University, Beijing, 100871, China, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, 100871, China; He, A., Institute of Molecular Medicine, Peking University, Beijing, 100871, China, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, 100871, China; Li, C.-Y., Institute of Molecular Medicine, Peking University, Beijing, 100871, China, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, 100871, China

Recommended Citation:
Li Y.,Li C.,Li S.,et al. Human exonization through differential nucleosome occupancy[J]. Proceedings of the National Academy of Sciences of the United States of America,2018-01-01,115(35)
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