globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1621438114
论文题名:
Polar delivery of Legionella type IV secretion system substrates is essential for virulence
作者: Jeong K.C.; Ghosal D.; Chang Y.-W.; Jensen G.J.; Vogel J.P.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2017
卷: 114, 期:30
起始页码: 8077
结束页码: 8082
语种: 英语
英文关键词: Bacterial pathogen ; Macrophage ; Polar localization ; Secretion
Scopus关键词: Article ; bacterial virulence ; cell division ; cellular distribution ; host cell ; Legionella pneumophila ; nonhuman ; phagosome ; polar body ; priority journal ; type IV secretion system ; animal ; cell polarity ; female ; Legionella pneumophila ; metabolism ; mouse ; pathogenicity ; physiology ; type IV secretion system ; Animals ; Cell Division ; Cell Polarity ; Female ; Legionella pneumophila ; Mice ; Type IV Secretion Systems
英文摘要: A recurrent emerging theme is the targeting of proteins to subcellular microdomains within bacterial cells, particularly to the poles. In most cases, it has been assumed that this localization is critical to the protein’s function. Legionella pneumophila uses a type IVB secretion system (T4BSS) to export a large number of protein substrates into the cytoplasm of host cells. Here we show that the Legionella export apparatus is localized to the bacterial poles, as is consistent with many T4SS substrates being retained on the phagosomal membrane adjacent to the poles of the bacterium. More significantly, we were able to demonstrate that polar secretion of substrates is critically required for Legionella’s alteration of the host endocytic pathway, an activity required for this pathogen’s virulence. © 2017, National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163811
Appears in Collections:气候变化与战略

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作者单位: Jeong, K.C., Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, United States, Department of Animal Sciences and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32611, United States; Ghosal, D., Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States; Chang, Y.-W., Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States; Jensen, G.J., Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, United States; Vogel, J.P., Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, United States

Recommended Citation:
Jeong K.C.,Ghosal D.,Chang Y.-W.,et al. Polar delivery of Legionella type IV secretion system substrates is essential for virulence[J]. Proceedings of the National Academy of Sciences of the United States of America,2017-01-01,114(30)
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