globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1916562117
论文题名:
Tunable and precise miniature lithium heater for point-of-care applications
作者: Udugama B.; Kadhiresan P.; Chan W.C.W.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期:9
起始页码: 4632
结束页码: 4641
语种: 英语
英文关键词: Chemical heater ; Diagnostics ; Point of care
Scopus关键词: lithium ; Article ; biochemical analysis ; chemical reaction kinetics ; controlled study ; diagnostic procedure ; electricity ; high temperature procedures ; point of care testing ; priority journal ; temperature measurement ; thermoregulation ; water flow
英文摘要: Point-of-care diagnostic assays often involve multistep reactions, requiring a wide range of precise temperatures. Although precise heating is critical to performing these assays, it is challenging to provide it in an electricity-free format away from established infrastructure. Chemical heaters are electricity-free and use exothermic reactions. However, they are unsuitable for point-of-care multistep reactions because they sacrifice portability, have a narrow range of achievable temperatures, and long ramp-up times. Here we developed a miniature heater by modulating the lithium-water reaction kinetics using bubbles in a channel. Our heaters are up to 8,000 times smaller than current devices and can provide precise (within 5 °C) and tunable heating from 37 °C to 65 °C (ΔTRT = 12 °C to 40 °C) with ramp-up times of a minute. We demonstrate field portablity and stability and show their use in an electricity-free multistep workflow that needs a range of temperatures. Ultimately, we envision providing better access to cutting edge biochemical techniques, including diagnostics, by making portable and electricity-free heating available at any location. © 2020 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/164304
Appears in Collections:气候变化与战略

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作者单位: Udugama, B., Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; Kadhiresan, P., Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; Chan, W.C.W., Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada, Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada, Materials Science and Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada

Recommended Citation:
Udugama B.,Kadhiresan P.,Chan W.C.W.. Tunable and precise miniature lithium heater for point-of-care applications[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(9)
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