globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2019.12.028
论文题名:
Restriction of exogenous DNA expression by SAMHD1
作者: Gu C.; Ming L.; Fang Y.; Liu X.; Zhang J.; Zelinskyy G.; Deng Q.; Liu J.; Xie Y.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期:7
起始页码: 573
结束页码: 586
语种: 英语
中文关键词: Exogenous DNA ; Hepatitis B virus ; Interferon regulatory factor-1 ; SAMHD1
英文关键词: Amino acids ; Antibiotics ; Diseases ; Glycoproteins ; Mammals ; Viruses ; Antigen expression ; DNA expressions ; Domain-containing proteins ; Hepatitis B virus ; Interferon regulatory factor-1 ; Novel functions ; SAMHD1 ; Virus productions ; DNA
英文摘要: SAMHD1 (Sterile Alpha Motif and Histidine-aspartate Domain containing protein 1) has been documented as a host factor that restricts HIV-1 and some DNA viruses. In this work, we attempted to explore possible effects of SAMHD1 on exogenous DNA and show that SAMHD1 exerts a general inhibition on the expression of exogenous DNA in vitro and in mice. This inhibition is achieved through repressing transcription of exogenous DNA. Intriguingly, unlike SAMHD1’s restriction of HIV-1, such restriction does not require the dNTPase or RNase activities, or T592 phosphorylation of SAMHD1. Mechanistically, SAMHD1 enhances the expression of interferon regulatory factor-1 (IRF1), while IRF1 upregulation was demonstrated to inhibit exogenous DNA expression in a similar fashion as SAMHD1. IFNλ1, whose induction has been associated with IRF1 activation, is dispensable for SAMHD1/IRF1-mediated restriction of exogenous DNA, and neither type I nor II interferons appear to be involved. We also demonstrate that SAMHD1/IRF1-mediated restriction can effectively inhibit hepatitis B virus (HBV) antigen expression and progeny virus production in mouse models. In conclusion, these data support restriction of exogenous DNA as a novel function of SAMHD1. © 2020 Science China Press
Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/169897
Appears in Collections:气候变化与战略

Files in This Item:

There are no files associated with this item.


作者单位: Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China; University Hospital Essen, Institute of Virology, Essen, 45147, Germany; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China; Children's Hospital, Fudan University, Shanghai, 201102, China

Recommended Citation:
Gu C.,Ming L.,Fang Y.,et al. Restriction of exogenous DNA expression by SAMHD1[J]. Science Bulletin,2020-01-01,65(7)
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gu C.]'s Articles
[Ming L.]'s Articles
[Fang Y.]'s Articles
百度学术
Similar articles in Baidu Scholar
[Gu C.]'s Articles
[Ming L.]'s Articles
[Fang Y.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gu C.]‘s Articles
[Ming L.]‘s Articles
[Fang Y.]‘s Articles
Related Copyright Policies
Null
收藏/分享
所有评论 (0)
暂无评论
 

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.