globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2020.03.040
论文题名:
Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features
作者: Lv X.; He C.; Huang C.; Hua G.; Chen X.; Timm B.K.; Maclin V.M.; Haggerty A.A.; Aust S.K.; Golden D.M.; Dave B.J.; Tseng Y.-A.; Chen L.; Wang H.; Chen P.; Klinkebiel D.L.; Karpf A.R.; Dong J.; Drapkin R.I.; Rueda B.R.; Davis J.S.; Wang C.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期:15
起始页码: 1281
结束页码: 1296
语种: 英语
中文关键词: Cell dedifferentiation ; Cell reprogramming ; Mesenchymal type of high grade serous cancer ; Ovarian granulosa cells ; The Hippo pathway ; YAP1 oncogene
英文关键词: Cell signaling ; Cells ; Diagnosis ; Diseases ; Physiology ; Early diagnosis ; Granulosa cells ; High grades ; High plasticity ; Ovarian cancers ; Research results ; Signaling pathways ; Cytology
英文摘要: Understanding the cell-of-origin of ovarian high grade serous cancer (HGSC) is the prerequisite for efficient prevention and early diagnosis of this most lethal gynecological cancer. Recently, a mesenchymal type of ovarian HGSC with the poorest prognosis among ovarian cancers was identified by both TCGA and AOCS studies. The cell-of-origin of this subtype of ovarian cancer is unknown. While pursuing studies to understand the role of the Hippo pathway in ovarian granulosa cell physiology and pathology, we unexpectedly found that the Yes-associated protein 1 (YAP1), the major effector of the Hippo signaling pathway, induced dedifferentiation and reprogramming of the ovarian granulosa cells, a unique type of ovarian follicular cells with mesenchymal lineage and high plasticity, leading to the development of high grade ovarian cancer with serous features. Our research results unveil a potential cell-of-origin for a subtype of HGSC with mesenchymal features. © 2020 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170000
Appears in Collections:气候变化与战略

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作者单位: Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States; Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE 68198, United States; College of Animal Sciences and Veterinary Medicine, Huazhong Agricultural University, Wuhan, 47000, China; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, United States; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, United States; Heartland Center for Reproductive Medicine, Omaha, NE 68198, United States; Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, United States; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, China; Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, United States; Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, United States

Recommended Citation:
Lv X.,He C.,Huang C.,et al. Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features[J]. Science Bulletin,2020-01-01,65(15)
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