globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2019.11.029
论文题名:
Salience processing by glutamatergic neurons in the ventral pallidum
作者: Wang F.; Zhang J.; Yuan Y.; Chen M.; Gao Z.; Zhan S.; Fan C.; Sun W.; Hu J.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期:5
起始页码: 389
结束页码: 401
语种: 英语
中文关键词: Aversion ; Glutamate ; Novelty ; Reward ; Salience ; Ventral pallidum (VP)
英文关键词: Aversion ; Glutamate ; Novelty ; Reward ; Salience ; Ventral pallidum (VP) ; Neurons
英文摘要: Organisms must make sense of a constant stream of sensory inputs from both internal and external sources which compete for attention by determining which ones are salient. The ability to detect and respond appropriately to potentially salient stimuli in the environment is critical to all organisms. However, the neural circuits that process salience are not fully understood. Here, we identify a population of glutamatergic neurons in the ventral pallidum (VP) that play a unique role in salience processing. Using cell-type-specific fiber photometry, we find that VP glutamatergic neurons are robustly activated by a variety of aversion- and reward-related stimuli, as well as novel social and non-social stimuli. Inhibition of the VP glutamatergic neurons reduces the ability to detect salient stimuli in the environment, such as aversive cue, novel conspecific and novel object. Besides, VP glutamatergic neurons project to both the lateral habenula (LHb) and the ventral tegmental area (VTA). Together, our findings demonstrate that the VP glutamatergic neurons participate in salience processing and therefore provide a new perspective on treating several neuropsychiatric disorders, including dementia and psychosis. © 2019
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170058
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作者单位: School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Columbia University, New York, NY 10027, United States; iHuman Institute, ShanghaiTech University, Shanghai, 201210, China; Chinese Institute for Brain Research, Beijing, 102206, China; School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226019, China

Recommended Citation:
Wang F.,Zhang J.,Yuan Y.,et al. Salience processing by glutamatergic neurons in the ventral pallidum[J]. Science Bulletin,2020-01-01,65(5)
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