DOI: 10.1016/j.scib.2020.03.028
论文题名: Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis
作者: Wang X. ; Zhang Y. ; Wang X. ; Dai J. ; Hua R. ; Zeng S. ; Li H.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期: 14 起始页码: 1203
结束页码: 1216
语种: 英语
中文关键词: Anterior-dorsal BNST
; Anxiety
; CRH
; PKC-δ
英文关键词: Brain
; Computer viruses
; Cytology
; Electrophysiology
; Neurons
; Physiological models
; Timing circuits
; Viruses
; Anterior-dorsal BNST
; Anxiety
; Corticotropin-releasing hormone
; Functional heterogeneity
; Long-range connectivities
; Physiological response
; Protein kinase c deltas
; Whole cell patch clamp
; Cells
英文摘要: The bed nucleus of the stria terminalis (BNST) plays a critical role in regulating anxiety, yet the involved specific cell types and their connections functioning in anxiety-related behaviors remains elusive. Here we identified two cell subpopulations—corticotropin-releasing hormone-positive (CRH+) and protein kinase C-δ-positive (PKC-δ+) neurons—each displayed discrete emotionally valenced behaviors in the anterior-dorsal BNST (adBNST). Using whole-cell patch-clamp recordings and virus-assisted circuit tracing techniques, we delineated the local and long-range connectivity networks in a cell-type-specific manner. The results show that the CRH+ and PKC-δ+ neurons received inputs from similar brain regions and exhibited significant differences in the downstream projection density. In addition, in vivo calcium imaging as well as gain- and loss-of-function studies characterized the physiological response properties and the functional heterogeneities in modulating anxiety, further suggesting the similarity and individuality between the two adBNST cell types. These results provide novel insights into the circuit architecture of adBNST neurons underlying the functionally specific neural pathways that relate to anxiety disorders. © 2020 Science China Press Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170075
Appears in Collections: 气候变化与战略
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作者单位: Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China; Ministry of Education Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, 430074, China
Recommended Citation:
Wang X.,Zhang Y.,Wang X.,et al. Anxiety-related cell-type-specific neural circuits in the anterior-dorsal bed nucleus of the stria terminalis[J]. Science Bulletin,2020-01-01,65(14)