DOI: 10.1016/j.scib.2019.12.006
论文题名: Cathepsin C promotes the progression of periapical periodontitis
作者: Yin W. ; Dong M. ; Ye D. ; Liu Q. ; Liu S. ; Shi C. ; Bai H. ; Wang Q. ; Yang X. ; Wang L. ; Niu W.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期: 11 起始页码: 951
结束页码: 957
语种: 英语
中文关键词: Cathepsin C
; Periapical periodontitis
; Receptor activator of nuclear factor-κB ligand
; Tartrate resistant acid phosphatase
英文关键词: Bone
; Ligands
; Mammals
; Pathology
; Phosphatases
; Surgery
; Correlation analysis
; Infectious disease
; Inflammatory cells
; Nuclear factor kappaB
; Nuclear factors
; Periapical periodontitis
; Receptor activator
; Tartrate-resistant acid phosphatase
; Diseases
英文摘要: Although the role of cathepsin C (Cat C) in inflammation is gradually being elucidated, its function in periapical periodontitis, which is one of the most common infectious diseases worldwide, has not been studied. This study evaluated a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) knock-down (KD) mice, which was constructed with a tetracycline operator, to evaluate the role of Cat C in the pathogenesis and progression of periapical periodontitis. Our results showed, for the first time, that there was a statistically significant increase in the expression of Cat C as periapical periodontitis progressed; this increase started from 1 week after surgery and reached a peak at 3 weeks after surgery, before gradually decreasing. The volume of periapical bone resorption in Cat C KD mice was significantly smaller than that in wild-type mice at 3 and 4 weeks after surgery (P<0.05). Inflammatory cell infiltration into the apical tissues of wild-type mice was also significantly higher than that of Cat C KD mice. The expression of receptor activator of nuclear factor-κB ligand (RANKL) in wild-type mice was also higher than that in Cat C KD mice. The difference in the number of osteoclasts in the apical area between the two groups was statistically significant after 2 weeks. Correlation analysis showed that there was a significant correlation between Cat C and RANKL expression (r= 0.835). Therefore, our data indicated that Cat C promoted the apical inflammation and bone destruction in mice. © 2019 Science China Press Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170131
Appears in Collections: 气候变化与战略
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作者单位: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine (Ministry of Education), School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China; Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, One Medical Center Drive, Lebanon, NH 03756, United States; School of Stomatology, Dalian Medical University, Dalian, 116044, China; Hospital of Stomatology, Yiwu City, Jinhua 322005, China
Recommended Citation:
Yin W.,Dong M.,Ye D.,et al. Cathepsin C promotes the progression of periapical periodontitis[J]. Science Bulletin,2020-01-01,65(11)