globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2019.10.023
论文题名:
Immunotherapeutic silk inverse opal particles for post-surgical tumor treatment
作者: Zhang H.; Liu Y.; Chen G.; Wang H.; Chen C.; Li M.; Lu P.; Zhao Y.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2020
卷: 65, 期:5
起始页码: 380
结束页码: 388
语种: 英语
中文关键词: Biomaterial ; Drug delivery ; Hydrogel ; Inverse opal ; Silk fibroin ; Tumor immunology
英文关键词: Bioactivity ; Biocompatibility ; Biomaterials ; Cell adhesion ; Diseases ; Drug delivery ; Hydrogels ; Scaffolds (biology) ; Surgery ; Tissue regeneration ; Colloid crystals ; Immunotherapeutic ; Inverse opal ; Silk fibroin ; Surgical resection ; Therapeutic efficacy ; Treatment failure ; Tumor immunologies ; Tumors
英文摘要: Recurrence of malignant tumor after surgical resection is the main reason of cancer treatment failure. Here, a novel kind of silk inverse opal particles (SIOPs) for post-surgical tumor treatment is presented, and it is derived from colloid crystal bead templates by negatively replicating. Because of their abundant uniform nanopores, interconnected nanochannels and excellent biocompatibility, SIOPs could not only carry great amount of anti-tumor drugs for tumor therapy, but also could provide support for cell adhesion, proliferation and differentiation as the 3D spherical scaffolds which is beneficial to the tissue repair at resection sites. It is demonstrated that the antibody drugs could maintain their high biological activity without any influences during the preparation of SIOPs and these particles were able to enhance the therapeutic efficacy and promote tissue regeneration after surgical resection with their multifunctional features. These prominent properties indicate the great potentials of SIOPs as a promising strategy for efficient postoperative cancer therapy. © 2019 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170148
Appears in Collections:气候变化与战略

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作者单位: State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China; Department of Medical Oncology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, 214023, China; Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China

Recommended Citation:
Zhang H.,Liu Y.,Chen G.,et al. Immunotherapeutic silk inverse opal particles for post-surgical tumor treatment[J]. Science Bulletin,2020-01-01,65(5)
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