globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2020.09.021
Title:
Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs
Author: Cao X.; Liu W.-P.; Cheng L.-G.; Li H.-J.; Wu H.; Liu Y.-H.; Chen C.; Xiao X.; Li M.; Wang G.-D.; Zhang Y.-P.
Source Publication: Science Bulletin
ISSN: 20959273
Publishing Year: 2021
Volume: 66, Issue:2
pages begin: 187
pages end: 196
Language: 英语
keyword in Chinese: Circling behavior ; Domestic dogs ; Genetic convergence ; Obsessive-compulsive disorder ; Whole genome sequencing
Keyword: Gene expression ; Biological mechanisms ; Functional exploration ; Genome-wide association studies ; Heterogeneous collections ; Obsessive compulsive disorders ; Population differentiations ; Strong convergence ; Whole genome analysis ; Risk assessment
English Abstract: Obsessive-compulsive disorder (OCD) represents a heterogeneous collection of diseases with diverse levels of phenotypic, genetic, and etiologic variability, making it difficult to identify the underlying genetic and biological mechanisms in humans. Domestic dogs exhibit several OCD-like behaviors. Using continuous circling as a representative phenotype for OCD, we screened two independent dog breeds, the Belgian Malinois and Kunming Dog and subsequently sequenced ten circling dogs and ten unaffected dogs for each breed. Using population differentiation analyses, we identified 11 candidate genes in the extreme tail of the differentiated regions between cases and controls. These genes overlap significantly with genes identified in a genome wide association study (GWAS) of human OCD, indicating strong convergence between humans and dogs. Through gene expressional analysis and functional exploration, we found that two candidate OCD risk genes, PPP2R2B and ADAMTSL3, affected the density and morphology of dendritic spines. Therefore, changes in dendritic spine may underlie some common biological and physiological pathways shared between humans and dogs. Our study revealed an unprecedented level of convergence in OCD shared between humans and dogs, and highlighted the importance of using domestic dogs as a model species for many human diseases including OCD. © 2020 Science China Press
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Document Type: 期刊论文
Identifier: http://119.78.100.158/handle/2HF3EXSE/170202
Appears in Collections:气候变化与战略

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Affiliation: State Key Laboratory of Genetic Resources and Evolution and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; Department of Laboratory Animal Science, Kunming Medical University, Kunming, 650500, China; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650223, China; Kunming Police Dog Base, Ministry of Public Security, Kunming, 650204, China; Laboratory for Conservation and Utilization of Bio-resource & Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China; KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China

Recommended Citation:
Cao X.,Liu W.-P.,Cheng L.-G.,et al. Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs[J]. Science Bulletin,2021-01-01,66(2)
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