globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.02.002
论文题名:
Chromosome-scale genomes provide new insights into subspecies divergence and evolutionary characteristics of the giant panda
作者: Guang X.; Lan T.; Wan Q.-H.; Huang Y.; Li H.; Zhang M.; Li R.; Zhang Z.; Lei Y.; Zhang L.; Zhang H.; Li D.; Li X.; Li H.; Xu Y.; Qiao M.; Wu D.; Tang K.; Zhao P.; Lin J.-Q.; Kumar Sahu S.; Liang Q.; Jiang W.; Zhang D.; Xu X.; Liu X.; Lisby M.; Yang H.; Kristiansen K.; Liu H.; Fang S.-G.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
语种: 英语
中文关键词: Chromosome-level genome ; Divergence time ; Giant panda ; Inner organ size ; Reduced fertility
英文关键词: Transcription ; Body sizes ; Chromosome-level genome ; Divergence time ; Giant panda ; High quality ; Inner organ size ; Reduced fertility ; Regulatory elements ; Sichuan ; Species specifics ; Cell proliferation
英文摘要: Extant giant pandas are divided into Sichuan and Qinling subspecies. The giant panda has many species-specific characteristics, including comparatively small organs for body size, small genitalia of male individuals, and low reproduction. Here, we report the most contiguous, high-quality chromosome-level genomes of two extant giant panda subspecies to date, with the first genome assembly of the Qinling subspecies. Compared with the previously assembled giant panda genomes based on short reads, our two assembled genomes increased contiguity over 200-fold at the contig level. Additional sequencing of 25 individuals dated the divergence of the Sichuan and Qinling subspecies into two distinct clusters from 10,000 to 12,000 years ago. Comparative genomic analyses identified the loss of regulatory elements in the dachshund family transcription factor 2 (DACH2) gene and specific changes in the synaptotagmin 6 (SYT6) gene, which may be responsible for the reduced fertility of the giant panda. Positive selection analysis between the two subspecies indicated that the reproduction-associated IQ motif containing D (IQCD) gene may at least partly explain the different reproduction rates of the two subspecies. Furthermore, several genes in the Hippo pathway exhibited signs of rapid evolution with giant panda-specific variants and divergent regulatory elements, which may contribute to the reduced inner organ sizes of the giant panda. © 2021 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170252
Appears in Collections:气候变化与战略

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作者单位: MOE Key Laboratory of Biosystems Homeostasis & Protection, State Conservation Centre for Gene Resources of Endangered Wildlife, College of Life Sciences, Zhejiang University, Hangzhou, 310058, China; State Key Laboratory of Agricultural Genomics, BGI-Shenzhen, Shenzhen, 518083, China; Key Laboratory of State Forestry and Grassland Administration (State Park Administration) on Conservation Biology of Rare Animals in the Giant Panda National Park, China Conservation and Research Center for the Giant Panda, Dujiangyan, 611830, China; Novogene Bioinformatics Institute, Beijing, 100029, China; Qinling Research Center of Giant Panda Breeding, Shaanxi Academy of Forestry, Xian, 710082, China; China Wildlife Conservation Association, Beijing, 100714, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, DK-2100, Denmark; Guangdong Provincial Key Laboratory of Genome Read and Write, BGI-Shenzhen, Shenzhen, 518120, China; Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Shenzhen, 518120, China; Qingdao-Europe Advanced Institute for Life Sciences, Qingdao, 266555, China

Recommended Citation:
Guang X.,Lan T.,Wan Q.-H.,et al. Chromosome-scale genomes provide new insights into subspecies divergence and evolutionary characteristics of the giant panda[J]. Science Bulletin,2021-01-01
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