globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.03.005
论文题名:
Acidic pH transiently prevents the silencing of self-renewal and dampens microRNA function in embryonic stem cells
作者: Guo W.; Wang S.; Zhang X.; Shi M.; Duan F.; Hao J.; Gu K.; Quan L.; Wu Y.; Liang Z.; Wang Y.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:13
起始页码: 1319
结束页码: 1329
语种: 英语
中文关键词: Acidic pH ; Embryonic stem cells ; Glycolysis ; Lactate ; Pluripotency
英文关键词: Cytology ; Diseases ; Gene expression ; Pathology ; Proteins ; RNA ; Acidic pH ; Cancer cells ; Cell-fate ; Condition ; Embryonic stem cells ; Genes expression ; Mice embryonic stem cells ; Pluripotency ; Self renewal ; Stem-cell ; Stem cells
英文摘要: Enhanced glycolysis is a distinct feature associated with numerous stem cells and cancer cells. However, little is known about its regulatory roles in gene expression and cell fate determination. Here, we confirm that glycolytic metabolism and lactate production decrease during the differentiation of mouse embryonic stem cells (mESCs). Importantly, acidic pH due to lactate accumulation can transiently prevent the silencing of mESC self-renewal in differentiation conditions. Furthermore, acidic pH partially blocks the differentiation of human ESCs (hESCs). Mechanistically, acidic pH downregulates AGO1 protein and de-represses a subset of mRNA targets of miR-290/302 family of microRNAs which facilitate the exit of naive pluripotency state in mESCs. Interestingly, AGO1 protein is also downregulated by acidic pH in cancer cells. Altogether, this study provides insights into the potential function and underlying mechanism of acidic pH in pluripotent stem cells (PSCs). © 2021 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170258
Appears in Collections:气候变化与战略

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作者单位: Department of Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University, Beijing, 100871, China; Department of Pathology, Molecular Pathology Research Centre, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China

Recommended Citation:
Guo W.,Wang S.,Zhang X.,et al. Acidic pH transiently prevents the silencing of self-renewal and dampens microRNA function in embryonic stem cells[J]. Science Bulletin,2021-01-01,66(13)
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