globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.01.010
论文题名:
Binding of the SARS-CoV-2 spike protein to glycans
作者: Hao W.; Ma B.; Li Z.; Wang X.; Gao X.; Li Y.; Qin B.; Shang S.; Cui S.; Tan Z.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:12
起始页码: 1205
结束页码: 1214
语种: 英语
中文关键词: Glycan microarray ; Heparan sulfate ; SARS-CoV-2 S protein ; Sialic acid ; Sulfation ; Surface plasmon resonance
英文关键词: Antiviral agents ; Carboxylic acids ; Cell membranes ; Polysaccharides ; Proteins ; Sulfur compounds ; Viruses ; Cell surfaces ; Glycan microarrays ; Glycans ; Heparan sulphate ; Host cells ; SARS-CoV-2 S protein ; Sialic acids ; Spike protein ; Sulphation ; Surface-plasmon resonance ; Surface plasmon resonance
英文摘要: The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing glycolipids/glycoproteins. In this study, we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2, SARS-CoV, and Middle East respiratory disease (MERS)-CoV to these glycans. Our results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner and no binding with sialic acid residues was detected. Overall, this work suggests that HS binding may be a general mechanism for the attachment of these coronaviruses to host cells, and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses. © 2021 Science China Press
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被引频次[WOS]:74   [查看WOS记录]     [查看WOS中相关记录]
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170262
Appears in Collections:气候变化与战略

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作者单位: NHC Key Laboratory of Systems Biology of Pathogens, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder, CO 80303, United States; School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China

Recommended Citation:
Hao W.,Ma B.,Li Z.,et al. Binding of the SARS-CoV-2 spike protein to glycans[J]. Science Bulletin,2021-01-01,66(12)
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