globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2020.12.027
论文题名:
Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6
作者: Jin L.; Cao L.; Zhu Y.; Cao J.; Li X.; Zhou J.; Liu B.; Zhao T.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:8
起始页码: 803
结束页码: 812
语种: 英语
中文关键词: CAR-T ; CCL20 ; CCR6 ; Lung cancer ; Migration
英文关键词: Antigens ; Biological organs ; Diseases ; Gene expression ; Mammals ; T-cells ; Tumors ; Antigen receptors ; Chemokine ligands ; Chemokine receptors ; Clinical development ; Ectopic expressions ; Gene expression profiling ; Interactive analysis ; Therapeutic efficacy ; Cytology
英文摘要: Chimeric antigen receptor-T (CAR-T) cells have limited therapeutic efficacy against solid tumors, partially due to their limited ability to reach and invade into the neoplastic foci. By gene expression profiling interactive analysis, we identified that the C–C motif chemokine ligand (CCL) 20 is highly expressed in lung and other most incidence and/or mortality cancers such as colon, rectum, stomach, and liver cancers. Forced expression of C–C motif chemokine receptor 6 (CCR6), the biunique receptor of CCL20, results in robust trafficking of CAR-T cells toward CCL20-secreting tumor cells. In a lung cancer xenograft mouse model, CCR6-expressing CAR-T cells efficiently migrate to and infiltrate into solid tumors upon infusion, leading to effective tumor clearance and significantly prolonged survival of tumor-bearing mice. In addition, culturing CCR6-CAR-T cells with interleukin (IL)-7 and IL-15 further improved their anti-lung cancer activity. Our findings provide supporting evidence for the clinical development of chemokine receptor-engineered CAR-T cells for solid tumor immunotherapy. © 2020 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170291
Appears in Collections:气候变化与战略

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作者单位: State Key Laboratory of Stem Cell and Reproductive Biology, Institute for Stem Cell and Regeneration, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Department of Thoracic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China; State Key Laboratory of Proteomics, Translational Medicine Center of Stem Cells, 307-Ivy Translational Medicine Center, Laboratory of Oncology, Affiliated Hospital, Academy of Military Medical Sciences, Beijing, 100071, China

Recommended Citation:
Jin L.,Cao L.,Zhu Y.,et al. Enhance anti-lung tumor efficacy of chimeric antigen receptor-T cells by ectopic expression of C–C motif chemokine receptor 6[J]. Science Bulletin,2021-01-01,66(8)
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