DOI: 10.1016/j.scib.2021.02.010
论文题名: The role of iron homeostasis in remodeling immune function and regulating inflammatory disease
作者: Mu Q. ; Chen L. ; Gao X. ; Shen S. ; Sheng W. ; Min J. ; Wang F.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期: 17 起始页码: 1806
结束页码: 1816
语种: 英语
中文关键词: Anemia of inflammation
; Ferroptosis
; Inflammatory response
; Iron homeostasis
; Iron overload
英文关键词: Cell signaling
; Diseases
; Metabolism
; Pathology
; Trace elements
; Anemia of inflammation
; Biological process
; Ferroptosis
; Immune function
; Inflammatory disease
; Inflammatory response
; Iron homeostasis
; Iron metabolism
; Iron overloads
; Traces elements
; Iron
英文摘要: The essential trace element iron regulates a wide range of biological processes in virtually all living organisms. Because both iron deficiency and iron overload can lead to various pathological conditions, iron homeostasis is tightly regulated, and understanding this complex process will help pave the way to developing new therapeutic strategies for inflammatory disease. In recent years, significant progress has been made with respect to elucidating the roles of iron and iron-related genes in the development and maintenance of the immune system. Here, we review the timing and mechanisms by which systemic and cellular iron metabolism are regulated during the inflammatory response and during infectious disease, processes in which both the host and the pathogen compete for iron. We also discuss the evidence and implications that immune cells such as macrophages, T cells, and B cells require sufficient amounts of iron for their proliferation and for mediating their effector functions, in which iron serves as a co-factor in toll-like receptor 4 (TLR4) signaling, mitochondrial respiration, posttranslational regulation, and epigenetic modification. In addition, we discuss the therapeutic implications of targeting ferroptosis, iron homeostasis and/or iron metabolism with respect to conferring protection against pathogen infection, controlling inflammation, and improving the efficacy of immunotherapy. © 2021 Science China Press Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170362
Appears in Collections: 气候变化与战略
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作者单位: The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Zhejiang University School of Medicine, Hangzhou, 310058, China; Hengyang Medical School, University of South China, Hengyang, 421001, China
Recommended Citation:
Mu Q.,Chen L.,Gao X.,et al. The role of iron homeostasis in remodeling immune function and regulating inflammatory disease[J]. Science Bulletin,2021-01-01,66(17)