globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.01.026
论文题名:
LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia
作者: Shi L.-N.; Zhou Y.; Wu C.; Huang W.; Yuan F.; Chen J.; Wu Z.; Tu W.; Chen H.; Chen Q.; Zhu M.; Peng H.; Yang Y.; Tang H.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
语种: 英语
中文关键词: Alveolar macrophages ; Influenza A virus ; LIGHT/TNFSF14 ; Natural killer T cells
英文关键词: Biological organs ; Cell death ; Macrophages ; Mammals ; T-cells ; Tissue ; Alveolar macrophages ; Cell-be ; Cell/B.E ; Cell/BE ; Cellulars ; Influenza A virus ; LIGHT/TNFSF14 ; Natural killer T cell ; Pathogenics ; T lymphocytes ; Viruses
英文摘要: CD1d-restricted natural killer T (NKT) cells are innate-like T lymphocytes with protective or pathogenic roles in the development of influenza pneumonia. Here, we show that lung-infiltrated and activated NKT cells are the major cellular source of LIGHT/TNFSF14, which determines the severity of pulmonary pneumonia by highly deteriorative influenza A virus (IAV) infection. Compared to wild-type mice, LIGHT−/− mice exhibit much lower morbidity and mortality to IAV, due to alleviated lung damage and reduced apoptosis of alveolar macrophages (AMs). LIGHT preferentially promotes cell death of lymphotoxin β receptors positive (LTβR+) AMs but not herpesvirus entry mediator positive (HVEM+) AMs. Therefore, these results suggest that NKT-derived LIGHT augments cell death of the tissue protective AMs in exacerbating lung pathology and susceptibility to fatal influenza infection. Suppression of LIGHT signaling might be a viable option in the treatment of influenza-associated acute respiratory distress syndrome. © 2021 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170384
Appears in Collections:气候变化与战略

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作者单位: CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; Department of Infectious Disease, Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China; CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; Center for Public Health Research and State Key Laboratory of Analytical Chemistry for Life Sciences, Nanjing University, Nanjing, 210093, China; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, 999077, Hong Kong; The Pateurien College, Soochow University, Suzhou, 215006, China; The Graduate School of University of Chinese Academy of Sciences, Beijing, 100049, China

Recommended Citation:
Shi L.-N.,Zhou Y.,Wu C.,et al. LIGHT of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia[J]. Science Bulletin,2021-01-01
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