DOI: 10.1016/j.scib.2020.10.021
论文题名: Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis
作者: Yang J. ; Ding L. ; Yu L. ; Wang Y. ; Ge M. ; Jiang Q. ; Chen Y.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期: 5 起始页码: 464
结束页码: 477
语种: 英语
中文关键词: Autophagy
; Ferroptosis
; Manganese oxide
; Mesoporous silica
; Trehalose
; Tumor therapy
英文关键词: Biocompatibility
; Diseases
; Medical nanotechnology
; Nanoparticles
; Peptides
; Tumors
; Antitumor effect
; Cancer cells
; Glutathione peroxidase
; Glutathiones
; PH sensitivity
; Programmed cell deaths
; Tumor therapy
; Tumor treatment
; Cell death
英文摘要: Ferroptosis and autophagy, playing significant roles in tumor treatment, are two typical forms of the programmed cell death. However, the rational combination of ferroptosis and autophagy for synergistic tumor therapy is still highly challenging. Herein, we report on an intriguing nanomedicine strategy for achieving autophagy-enhanced ferroptosis on efficiently combating cancer, which was based on the construction of trehalose-loaded mSiO2@MnOx-mPEG (TreMMM) nanoparticles with satisfactory biocompatibility. The nanoparticles are endowed with high glutathione (GSH) consumption efficiency, thereby inducing cancer-cell ferroptosis via inactivating glutathione peroxidases 4 (GPX4). Subsequently, the TreMMM degradation due to the GSH depletion and pH sensitivity contributed to the trehalose release for inducing autophagy, promoting/enhancing ferroptosis by NCOA4-mediated degradation of ferritin. A substantial in vitro and in vivo antitumor effect was achieved by such an intriguing autophagy-enhanced ferroptosis. Therefore, the rational combination of GSH-consumption-induced ferroptosis and trehalose-induced autophagy by nanomedicine design provides an alternative but effective strategy for tumor treatment. © 2020 Science China Press Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170468
Appears in Collections: 气候变化与战略
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作者单位: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China
Recommended Citation:
Yang J.,Ding L.,Yu L.,et al. Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis[J]. Science Bulletin,2021-01-01,66(5)