globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2020.11.001
论文题名:
The sulfur metabolism regulator MetR is a global regulator controlling phytochrome-dependent light responses in Aspergillus nidulans
作者: Yu Z.; Gao J.; Igbalajobi O.; Skoneczny M.; Sieńko M.; Maciejewska A.M.; Brzywczy J.; Fischer R.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:6
起始页码: 592
结束页码: 602
语种: 英语
中文关键词: Cys3 ; Met4 ; Phytochrome ; Sulfur metabolism ; Transcriptome
英文关键词: Amino acids ; Aspergillus ; Enzymes ; Metabolism ; Metabolites ; Sulfur compounds ; Transcription ; Aspergillus nidulans ; Expression analysis ; Expression controls ; Metabolic pathways ; Secondary metabolite production ; Signaling pathways ; Sulfur starvations ; Transcriptional regulator ; Sulfur
英文摘要: Phytochrome-dependent light signaling has been studied in several fungi. In Aspergillus nidulans light-stimulated phytochrome activates the high-osmolarity glycerol (HOG) signaling pathway and thereby controls the expression of a large number of genes, many of which are related to stress responses. In a genome-wide expression analysis in A. nidulans we found that phytochrome, fphA, is under strict expression control of the central regulator of the sulfur-starvation response, MetR. This transcriptional regulator is required for the expression of genes involved in inorganic sulfur assimilation. In the presence of organic sulfur, MetR is probably ubiquitinated and possibly degraded and the transcription of sulfur-assimilation genes, e.g., sulfate permease, is turned off. The expression analysis described here revealed, however, that MetR additionally controls the expression of hundreds of genes, many of which are required for secondary metabolite production. We also show that metR mutation phenocopies fphA deletion, and five other histidine-hybrid kinases are down-regulated in the metR1 mutant. Furthermore, we found that light and phytochrome regulate the expression of at least three carbon–sulfur hydrolases. This work is a further step towards understanding the interplay between light sensing and metabolic pathways. © 2020 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170487
Appears in Collections:气候变化与战略

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作者单位: Department of Microbiology, Institute for Applied Biosciences, Karlsruhe Institute of Technology (KIT)-South Campus, Karlsruhe, D-76131, Germany; The Key Laboratory of Plant Immunity, Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, National Engineering Research Center for Organic-based Fertilizers, Nanjing Agricultural University, Nanjing, 210095, China; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, 02-106, Poland; Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC VGT 1Z4, Canada

Recommended Citation:
Yu Z.,Gao J.,Igbalajobi O.,et al. The sulfur metabolism regulator MetR is a global regulator controlling phytochrome-dependent light responses in Aspergillus nidulans[J]. Science Bulletin,2021-01-01,66(6)
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