globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2021.02.011
论文题名:
Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision
作者: Zhang Y.; Yao L.; Li X.; Meng M.; Shang Z.; Wang Q.; Xiao J.; Gu X.; Xu Z.; Zhang X.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
语种: 英语
中文关键词: Binocular depth perception ; Collapsin response mediator protein-2 (CRMP2) ; Critical period plasticity ; Excitation-inhibition balance ; Primary visual cortex ; Schizophrenia
英文关键词: Behavioral research ; Binocular vision ; Binoculars ; Depth perception ; Diseases ; Electric network analysis ; Electrophysiology ; Neurons ; Timing circuits ; Binding proteins ; Binocular depth perception ; Collapsin response mediator protein-2 ; Critical period plasticity ; Critical periods ; Excitation-inhibition balance ; Human patients ; Microtubules ; Neuronal differentiation ; Primary visual cortex ; Proteins
英文摘要: Brain-specific loss of a microtubule-binding protein collapsin response mediator protein-2 (CRMP2) in the mouse recapitulates many schizophrenia-like behaviors of human patients, possibly resulting from associated developmental deficits in neuronal differentiation, path-finding, and synapse formation. However, it is still unclear how the Crmp2 loss affects neuronal circuit function and plasticity. By conducting in vivo and ex vivo electrophysiological recording in the mouse primary visual cortex (V1), we reveal that CRMP2 exerts a key regulation on the timing of postnatal critical period (CP) for experience-dependent circuit plasticity of sensory cortex. In the developing V1, the Crmp2 deficiency induces not only a delayed maturation of visual tuning functions but also a precocious CP for visual input-induced ocular dominance plasticity and its induction activity – coincident binocular inputs right after eye-opening. Mechanistically, the Crmp2 deficiency accelerates the maturation process of cortical inhibitory transmission and subsequently promotes an early emergence of balanced excitatory-inhibitory cortical circuits during the postnatal development. Moreover, the precocious CP plasticity results in deteriorated binocular depth perception in adulthood. Thus, these findings suggest that the Crmp2 deficiency dysregulates the timing of CP for experience-dependent refinement of circuit connections and further leads to impaired sensory perception in later life. © 2021 Science China Press
Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170510
Appears in Collections:气候变化与战略

Files in This Item:

There are no files associated with this item.


作者单位: State Key Laboratory of Cognitive Neuroscience & Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, China; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China

Recommended Citation:
Zhang Y.,Yao L.,Li X.,et al. Schizophrenia risk-gene Crmp2 deficiency causes precocious critical period plasticity and deteriorated binocular vision[J]. Science Bulletin,2021-01-01
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang Y.]'s Articles
[Yao L.]'s Articles
[Li X.]'s Articles
百度学术
Similar articles in Baidu Scholar
[Zhang Y.]'s Articles
[Yao L.]'s Articles
[Li X.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang Y.]‘s Articles
[Yao L.]‘s Articles
[Li X.]‘s Articles
Related Copyright Policies
Null
收藏/分享
所有评论 (0)
暂无评论
 

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.