globalchange  > 气候变化与战略
DOI: 10.1016/j.scib.2020.08.036
论文题名:
Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy
作者: Zhao C.; Xie P.; Yong T.; Huang W.; Liu J.; Wu D.; Ji F.; Li M.; Zhang D.; Li R.; Dong C.; Ma J.; Dong Z.; Liu S.; Cai Z.
刊名: Science Bulletin
ISSN: 20959273
出版年: 2021
卷: 66, 期:6
起始页码: 578
结束页码: 591
语种: 英语
中文关键词: Airborne fine particulate matter ; Cognitive and emotional disorders ; Gestational exposure ; Lipid metabolism ; Mass spectrometry imaging
英文关键词: Behavioral research ; Blood ; Brain ; Cerebrospinal fluid ; Mammals ; Mass spectrometry ; Particles (particulate matter) ; Plants (botany) ; Alzheimer's disease ; Fine particulate matter ; Hippocampal formation ; Human cerebrospinal fluid ; Intratracheal instillation ; Parkinson's disease ; Three dimensional imaging ; Toxicological effects ; Neurodegenerative diseases
英文摘要: Gestational exposure to PM2.5 is associated with adverse postnatal outcomes. PM2.5 can enter alveoli by using intratracheal instillation, even penetrate through lung cells into the blood circulation. Subsequently, they are transferred across the placenta and fetal blood brain barrier, causing the adverse birth outcomes of offspring. This study demonstrated that the gestational exposure resulted in cognitive and emotional disorders in female offspring although the offspring were not exposed to PM2.5. Placental metabolic pathways modulated fetal brain development and played a pivotal role for maternal-placental-fetal interactions in the fetal programming of adult behavioral and mental disorders. Samples of fetus, offspring hippocampus and placenta from the mice exposed to PM2.5 were investigated using a comprehensive approach including mass spectrometry-based lipidomics and three-dimensional imaging. The exposure induced the neuro-degeneration in hippocampus, impairment of placental cytoarchitecture, and reprogramming of lipidome, which might affect the modulation of maternal-fetal cross-talk and result in the behavior disorders of offspring. The variation of spatial distribution of lipids was profoundly affected in dorsal pallium and hippocampal formation regions of fetal brain, offspring hippocampus, as well as labyrinth and junctional zones of placenta. The abundance alteration of lipid markers associated with neurodegenerative diseases was validated in transgenic mouse model with Alzheimer's disease and human cerebrospinal fluid from patients with Parkinson's disease. The finding could help with the selection of more suitable heterogeneous-related substructures targeting PM2.5 exposure and the exploration of PM2.5-induced toxicological effects on neurodegenerative diseases. © 2020 Science China Press
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/170515
Appears in Collections:气候变化与战略

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作者单位: State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist UniversityHong Kong 999077, China; Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen, 518000, China; School of Chinese Medicine, Hong Kong Baptist UniversityHong Kong 999077, China; Department of Functional Neurology & Neurosurgery, First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen University School of Medicine, Shenzhen, 518000, China; Institute of Environmental Science, Shanxi University, Taiyuan, 030000, China; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China

Recommended Citation:
Zhao C.,Xie P.,Yong T.,et al. Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy[J]. Science Bulletin,2021-01-01,66(6)
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