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DOI:	10.1371/journal.pone.0087355
论文题名:	Population Genetic Structure and Isolation by Distance of Helicobacter pylori in Senegal and Madagascar
作者:	Bodo Linz; Clairette Romaine Raharisolo Vololonantenainab; Abdoulaye Seck; Jean-François Carod; Daouda Dia; Benoit Garin; Rado Manitrala Ramanampamonjy; Jean-Michel Thiberge; Josette Raymond; Sebastien Breurec
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2014
发表日期:	2014-1-30
卷:	9, 期:1
语种:	英语
英文关键词:	Helicobacter pylori ; Senegal ; Africa ; Madagascar ; Phylogeography ; Population genetics ; Human genetics ; Africans
英文摘要:	Helicobacter pylori has probably infected the human stomach since our origins and subsequently diversified in parallel with their human hosts. The genetic population history of H. pylori can therefore be used as a marker for human migration. We analysed seven housekeeping gene sequences of H. pylori strains isolated from 78 Senegalese and 24 Malagasy patients and compared them with the sequences of strains from other geographical locations. H. pylori from Senegal and Madagascar can be placed in the previously described HpAfrica1 genetic population, subpopulations hspWAfrica and hspSAfrica, respectively. These 2 subpopulations correspond to the distribution of Niger-Congo speakers in West and most of subequatorial Africa (due to Bantu migrations), respectively. H. pylori appears as a single population in Senegal, indicating a long common history between ethnicities as well as frequent local admixtures. The lack of differentiation between these isolates and an increasing genetic differentiation with geographical distance between sampling locations in Africa was evidence for genetic isolation by distance. The Austronesian expansion that started from Taiwan 5000 years ago dispersed one of the 10 subgroups of the Austronesian language family via insular Southeast Asia into the Pacific and Madagascar, and hspMaori is a marker for the entire Austronesian expansion. Strain competition and replacement of hspMaori by hpAfrica1 strains from Bantu migrants are the probable reasons for the presence of hspSAfrica strains in Malagasy of Southeast Asian descent. hpAfrica1 strains appear to be generalist strains that have the necessary genetic diversity to efficiently colonise a wide host spectrum.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087355&type=printable
Citation statistics:	被引频次[WOS]:13 [查看WOS记录] [查看WOS中相关记录]
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/19171
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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作者单位:

Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, United States of America;Laboratoire d’Anatomie et de Cytologie Pathologiques, Institut Pasteur, Antananarivo, Madagascar;Laboratoire de Biologie Médicale, Institut Pasteur, Dakar, Senegal;Centre de Biologie Clinique, Institut Pasteur, Antananarivo, Madagascar;Centre Hospitalier Le Dantec, Département de Gastro-entérologie, Dakar, Senegal;Laboratoire de Biologie Médicale, Institut Pasteur, Dakar, Senegal;Laboratoire de Bactériologie expérimentale, Institut Pasteur, Antananarivo, Madagascar;Centre Hospitalier Universitaire Joseph Ravoahangy Befelatanana, Département de Gastro-entérologie, Antananarivo, Madagascar;Plate-forme Génotypage des Pathogènes et Santé Publique, Institut Pasteur, Paris, France;Unité Postulante Pathogenèse de Helicobacter, Institut Pasteur, Paris, France;Laboratoire de Biologie Médicale, Institut Pasteur, Dakar, Senegal;Institut Pasteur, Laboratoire de Biologie médicale, Bangui, République Centrafricaine

Recommended Citation:

Bodo Linz,Clairette Romaine Raharisolo Vololonantenainab,Abdoulaye Seck,et al. Population Genetic Structure and Isolation by Distance of Helicobacter pylori in Senegal and Madagascar[J]. PLOS ONE,2014-01-01,9(1)

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