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DOI:	10.1371/journal.pone.0123509
论文题名:	Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel
作者:	Miguel A. Lanaspa; L. Elaine Epperson; Nanxing Li; Christina Cicerchi; Gabriela E. Garcia; Carlos A. Roncal-Jimenez; Jessica Trostel; Swati Jain; Colin T. Mant; Christopher J. Rivard; Takuji Ishimoto; Michiko Shimada; Laura Gabriela Sanchez-Lozada; Takahiko Nakagawa; Alkesh Jani; Peter Stenvinkel; Sandra L. Martin; Richard J. Johnson
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-4-9
卷:	10, 期:4
语种:	英语
英文关键词:	Fats ; Hibernation ; Uric acid ; Oxidation ; Summer ; Autumn ; Squirrels ; Winter
英文摘要:	Hibernating animals develop fatty liver when active in summertime and undergo a switch to a fat oxidation state in the winter. We hypothesized that this switch might be determined by AMP and the dominance of opposing effects: metabolism through AMP deaminase (AMPD2) (summer) and activation of AMP-activated protein kinase (AMPK) (winter). Liver samples were obtained from 13-lined ground squirrels at different times during the year, including summer and multiples stages of winter hibernation, and fat synthesis and β-fatty acid oxidation were evaluated. Changes in fat metabolism were correlated with changes in AMPD2 activity and intrahepatic uric acid (downstream product of AMPD2), as well as changes in AMPK and intrahepatic β-hydroxybutyrate (a marker of fat oxidation). Hepatic fat accumulation occurred during the summer with relatively increased enzymes associated with fat synthesis (FAS, ACL and ACC) and decreased enoyl CoA hydratase (ECH1) and carnitine palmitoyltransferase 1A (CPT1A), rate limiting enzymes of fat oxidation. In summer, AMPD2 activity and intrahepatic uric acid levels were high and hepatic AMPK activity was low. In contrast, the active phosphorylated form of AMPK and β-hydroxybutyrate both increased during winter hibernation. Therefore, changes in AMPD2 and AMPK activity were paralleled with changes in fat synthesis and fat oxidation rates during the summer-winter cycle. These data illuminate the opposing forces of metabolism of AMP by AMPD2 and its availability to activate AMPK as a switch that governs fat metabolism in the liver of hibernating ground squirrel.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123509&type=printable
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资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/20944
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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作者单位:

Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Department of Cell and Developmental Biology, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Department of Biochemistry and Molecular Genetics, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Laboratory of Renal Physiopathology and Nephrology Dept, INC Ignacio Chavez, Mexico City, Mexico;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Renal Medicine, Department of Clinical Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;Department of Cell and Developmental Biology, Aurora, CO, 80045, United States of America;Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, 80045, United States of America;Division of Nephrology, Eastern Colorado Health System, Department of Veteran Affairs, Denver, CO, United States of America

Recommended Citation:

Miguel A. Lanaspa,L. Elaine Epperson,Nanxing Li,et al. Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel[J]. PLOS ONE,2015-01-01,10(4)

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