全球变化知识资源中心

Knowledge Resources Center for Global Change


Email:
Passwd
验证:
	换一张
Have you forgotten your password? Stay signed in Log In

globalchange > 过去全球变化的重建

DOI:	10.1371/journal.pone.0115449
论文题名:	Differing Evolutionary Histories of the ACTN3*R577X Polymorphism among the Major Human Geographic Groups
作者:	Carlos Eduardo G. Amorim; Victor Acuña-Alonzo; Francisco M. Salzano; Maria Cátira Bortolini; Tábita Hünemeier
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-2-23
卷:	10, 期:2
语种:	英语
英文关键词:	Alleles ; Haplotypes ; Native Americans ; Evolutionary genetics ; Genomic databases ; Asia ; Homozygosity ; Phylogeography
英文摘要:	It has been proposed that the functional ACTN3*R577X polymorphism might have evolved due to selection in Eurasian human populations. To test this possibility we surveyed all available population-based data for this polymorphism and performed a comprehensive evolutionary analysis of its genetic diversity, in order to assess the action of adaptive and random mechanisms on its variation across human geographical distribution. The derived 577X allele increases in frequency with distance from Africa, reaching the highest frequencies on the American continent. Positive selection, detected by an extended haplotype homozygosisty test, was consistent only with the Eurasian data, but simulations with neutral models could not fully explain the results found in the American continent. It is possible that particularities of Native American population structure could be responsible for the observed allele frequencies, which would have resulted from a complex interaction between selective and random factors.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0115449&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/21419
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

Files in This Item:	Download All

File Name/ File Size	Content Type	Version	Access	License
journal.pone.0115449.PDF（505KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91501-970, Brazil;CAPES Foundation, Ministry of Education of Brazil, Brasília, 70040-020, Brazil;Unit of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de México, Mexico City 14000, Mexico;Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91501-970, Brazil;Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91501-970, Brazil;Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 91501-970, Brazil

Recommended Citation:

Carlos Eduardo G. Amorim,Victor Acuña-Alonzo,Francisco M. Salzano,et al. Differing Evolutionary Histories of the ACTN3*R577X Polymorphism among the Major Human Geographic Groups[J]. PLOS ONE,2015-01-01,10(2)

Service
	Recommend this item
	Sava as my favorate item
	Show this item's statistics
	Export Endnote File
Google Scholar
	Similar articles in Google Scholar
	[Carlos Eduardo G. Amorim]'s Articles
	[Victor Acuña-Alonzo]'s Articles
	[Francisco M. Salzano]'s Articles
百度学术
	Similar articles in Baidu Scholar
	[Carlos Eduardo G. Amorim]'s Articles
	[Victor Acuña-Alonzo]'s Articles
	[Francisco M. Salzano]'s Articles
CSDL cross search
	Similar articles in CSDL Cross Search
	[Carlos Eduardo G. Amorim]‘s Articles
	[Victor Acuña-Alonzo]‘s Articles
	[Francisco M. Salzano]‘s Articles
Related Copyright Policies
Null
收藏/分享