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DOI:	10.1371/journal.pone.0139811
论文题名:	Tracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences
作者:	Matthias Steglich; Andreas Nitsche; Lutz von Müller; Mathias Herrmann; Thomas A. Kohl; Stefan Niemann; Ulrich Nübel
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-10-7
卷:	10, 期:10
语种:	英语
英文关键词:	Clostridium difficile ; Germany ; Phylogenetic analysis ; Phylogeography ; Phylogenetics ; Mobile genetic elements ; Point mutation ; Sequence analysis
英文摘要:	We applied whole-genome sequencing to reconstruct the spatial and temporal dynamics underpinning the expansion of Clostridium difficile ribotype 027 in Germany. Based on re-sequencing of genomes from 57 clinical C. difficile isolates, which had been collected from hospitalized patients at 36 locations throughout Germany between 1990 and 2012, we demonstrate that C. difficile genomes have accumulated sequence variation sufficiently fast to document the pathogen's spread at a regional scale. We detected both previously described lineages of fluoroquinolone-resistant C. difficile ribotype 027, FQR1 and FQR2. Using Bayesian phylogeographic analyses, we show that fluoroquinolone-resistant C. difficile 027 was imported into Germany at least four times, that it had been widely disseminated across multiple federal states even before the first outbreak was noted in 2007, and that it has continued to spread since.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0139811&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/21500
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0139811.PDF（300KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Robert Koch Institute, Department of Infectious Diseases, Division of Nosocomial Pathogens and Antibiotic Resistances, Wernigerode, Germany;Robert Koch Institute, Centre for Biological Threats and Special Pathogens, ZBS 1 Highly Pathogenic Viruses, Berlin, Germany;University of Saarland Medical Centre, Institute of Medical Microbiology and Hygiene, National Consultant Laboratory for Clostridium difficile, Homburg, Germany;University of Saarland Medical Centre, Institute of Medical Microbiology and Hygiene, National Consultant Laboratory for Clostridium difficile, Homburg, Germany;Research Center Borstel, Molecular Mycobacteriology, Borstel, Germany;Research Center Borstel, Molecular Mycobacteriology, Borstel, Germany;German Center for Infection Research (DZIF), Partner Site Borstel, Borstel, Germany;Leibniz Institute DSMZ, Department of Microbial Genome Research, Braunschweig, Germany;German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig, Germany

Recommended Citation:

Matthias Steglich,Andreas Nitsche,Lutz von Müller,et al. Tracing the Spread of Clostridium difficile Ribotype 027 in Germany Based on Bacterial Genome Sequences[J]. PLOS ONE,2015-01-01,10(10)

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