globalchange  > 过去全球变化的重建
DOI: 10.1371/journal.pone.0134213
论文题名:
dTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila melanogaster
作者: Antara Das; Todd C. Holmes; Vasu Sheeba
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2015
发表日期: 2015-7-30
卷: 10, 期:7
语种: 英语
英文关键词: Neurons ; Drosophila melanogaster ; Circadian rhythms ; Humidity ; Chronobiology ; Ion channels ; Biological locomotion ; Insect physiology
英文摘要: Daily rhythms in Drosophila under semi-natural conditions (or SN) have received much recent attention. One of the striking differences in the behaviour of wild type flies under SN is the presence of an additional peak of activity in the middle of the day. This is referred to as the afternoon peak (A-peak) and is absent under standard laboratory regimes using gated light and temperature cues. Although previous reports identified the physical factors that contribute towards the A-peak there is no evidence for underlying molecular mechanisms or pathways that control A-peak. We report that the A-peak is mediated by thermosensitive dTRPA1 (drosophila Transient Receptor Potential- A1) ion channels as this peak is absent in dTRPA1 null mutants. Further, when natural cycles of light and temperature are simulated in the lab, we find that the amplitude of the A-peak is dTRPA1-dependent. Although a few circadian neurons express dTRPA1, we show that modulation of A-peak is primarily influenced by non-CRY dTRPA1 expressing neurons. Hence, we propose that A-peak of activity observed under SN is a temperature sensitive response in flies that is elicited through dTRPA1 receptor signalling.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134213&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/21673
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Evolutionary and Organismal Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, PB # 6436, Jakkur Post, Bangalore-560 064, India;Department of Physiology and Biophysics, University of California, Irvine, D340, Medical Sciences 1, Irvine, California, 92697–4560, United States of America;Evolutionary and Organismal Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, PB # 6436, Jakkur Post, Bangalore-560 064, India;Neuroscience Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, PB # 6436, Jakkur Post, Bangalore-560 064, India

Recommended Citation:
Antara Das,Todd C. Holmes,Vasu Sheeba. dTRPA1 Modulates Afternoon Peak of Activity of Fruit Flies Drosophila melanogaster[J]. PLOS ONE,2015-01-01,10(7)
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