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DOI:	10.1371/journal.pone.0125216
论文题名:	It’s Never over until It’s over: How Can Age and Ovarian Reserve Be Mathematically Bound through the Measurement of Serum AMH—A Study of 5069 Romanian Women
作者:	Bogdan Doroftei; Cristina Mambet; Mihaela Zlei
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2015
发表日期:	2015-4-24
卷:	10, 期:4
语种:	英语
英文关键词:	Assisted reproductive technology ; Geographical regions ; Data processing ; Romanians ; Female infertility ; Human genetics ; Menopause ; Romania
英文摘要:	Wide regional differences in the age-related Anti Mullerian hormone (AMH) regression patterns or age at onset of natural menopause have been reported, possibly reflecting genetic, socioeconomic, environmental, racial or ethnic peculiarities. Moreover, adaptation of AMH levels from different assays using regression functions may lack accuracy and externally defined references for AMH levels may not fully comply with a specific geographical area. The current study aimed to establish an accurate mathematical relationship between AMH serum values and age in a large group of women from Romania, as any consistent difference from previously reported regression models may aid in building specific profiles for the AMH decline with age in this geographical region. Our study pointed out to the quadratic regression as the most fitted pattern of correlation for all the age groups between 24 and 45. To our knowledge the current manuscript is based on the singular study carried out in this geographical region, generating a particular age-related pattern of association between age and serum AMH levels in women, regardless of their subjacent pathologies.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0125216&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/22287
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0125216.PDF（1514KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Obstetrics and Gynecology Department, Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania;Origyn Fertility Center, Iasi, Romania;Synevo Central Laboratory-Medicover Group, Bucuresti, Romania;Origyn Fertility Center, Iasi, Romania;Laboratory of Molecular Biology, Regional Institute of Oncology, Iasi, Romania

Recommended Citation:

Bogdan Doroftei,Cristina Mambet,Mihaela Zlei. It’s Never over until It’s over: How Can Age and Ovarian Reserve Be Mathematically Bound through the Measurement of Serum AMH—A Study of 5069 Romanian Women[J]. PLOS ONE,2015-01-01,10(4)

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