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DOI: 10.1371/journal.pone.0156864
论文题名:
Limited Genetic Diversity of Hepatitis B Virus in the General Population of the Offin River Valley in Ghana
作者: Kobina Assan Ampah; Carlos Augusto Pinho-Nascimento; Sarah Kerber; Prince Asare; Daniel De-Graft; Frank Adu-Nti; Izabel C. N. P. Paixão; Christian Niel; Dorothy Yeboah-Manu; Gerd Pluschke; Katharina Röltgen
刊名: PLOS ONE
ISSN: 1932-6203
出版年: 2016
发表日期: 2016-6-6
卷: 11, 期:6
语种: 英语
英文关键词: Ghana ; Rivers ; Sequence motif analysis ; DNA sequence analysis ; Hepatitis B virus ; Polymerase chain reaction ; Hepatitis delta virus ; Sequence analysis
英文摘要: Hepatitis B virus (HBV) infections account for approximately 780,000 deaths per year, most of which occur in the developing world. Co-infection with HBV and hepatitis delta virus (HDV) may lead to the most severe form of viral hepatitis. In Ghana, knowledge on the prevalence of HBV and HDV in the general population is scanty and the few genetic analyses of the prevailing HBV genotypes are dating back more than a decade. In the present study, 1,323 serum samples from individuals living in a rural area (Offin river valley) of Ghana were analyzed for the presence of the hepatitis B surface antigen (HBsAg). Positive sera were subsequently tested for the presence of anti-HDV antibodies. A total of 107 (8%) sera were HBsAg positive with an 8.4% prevalence of anti-HDV antibodies among the HBsAg positives. Phylogenetic analysis based on HBV pre-S/S sequences, attributed all 52 typable samples to genotype E. All belonged to serotype ayw4. While 19 sequences clustered with those from a number of African countries, the other 33 formed a separate cluster distinguished by an intergroup mean distance of 1.5% from the pan-African HBV/E cluster. Successful implementation of HBV vaccination in the region was reflected by the low HBsAg carrier rate of 1.8% among children ≤11 years.
URL: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156864&type=printable
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/23320
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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作者单位: Swiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland;University of Basel, Basel, Switzerland;Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana;Laboratory of Molecular Virology, Biology Institute, Fluminense Federal University, Niterói, Brazil;Swiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland;University of Basel, Basel, Switzerland;Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana;Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana;Radford University College, Accra, Ghana;Laboratory of Molecular Virology, Biology Institute, Fluminense Federal University, Niterói, Brazil;Laboratory of Molecular Virology, Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil;Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana;Swiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland;University of Basel, Basel, Switzerland;Swiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland;University of Basel, Basel, Switzerland

Recommended Citation:
Kobina Assan Ampah,Carlos Augusto Pinho-Nascimento,Sarah Kerber,et al. Limited Genetic Diversity of Hepatitis B Virus in the General Population of the Offin River Valley in Ghana[J]. PLOS ONE,2016-01-01,11(6)
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