globalchange  > 过去全球变化的重建
DOI: 10.1371/journal.pone.0166351
Title:
Gallstones: A Worldwide Multifaceted Disease and Its Correlations with Gallbladder Carcinoma
Author: Raj Kumar Sharma; Kanchan Sonkar; Neeraj Sinha; Pradeep Rebala; Ahmad Ebrah Albani; Anu Behari; Duvvuri Nageshwar Reddy; Alvina Farooqui; Vinay Kumar Kapoor
Source Publication: PLOS ONE
ISSN: 1932-6203
Publishing Year: 2016
Date Published: 2016-11-10
Volume: 11, Issue:11
Language: 英语
Keyword: Cholesterol ; India ; Bilirubin ; NMR spectroscopy ; Solid-state NMR spectroscopy ; Absorption spectroscopy ; Geographical regions ; Bile
English Abstract: Background Gallstones (GS) associated diseases are among the most recurrent and frequent diseases delineated in India and United Arab Emirates. Several reports suggest that the association of GS with gallbladder cancer (GBC) is very high in Northern part of India; however, its occurrence in UAE and Southern part of India is notably low. Therefore, in the present study, we aimed to perform compositional analysis of GS in three different geographical areas by Solid State Nuclear Magnetic Resonance and Fourier Transformed Infrared spectroscopy. Methods Natural abundance 13C cross polarization magic angle spinning Nuclear Magnetic Resonance and Fourier Transform Infrared spectroscopy is employed for the analysis of human gallstone. Results Cholesterol, bilirubin and calcium carbonate were present in variant concentrations in GS obtained from three different geographical regions. Cholesterol was present predominantly in gallstones from North India. Bilirubin was found to be a main constituent in gallstones pertaining to South India. Whereas GS from UAE showed both cholesterol and bilirubin as their major constituents. Calcium carbonate was found in varying concentrations in gallstones acquired from different regions. Conclusion Variation in environmental condition and dietary habits may contribute and affect the GS formation. Alterations in bile composition influence the GB and augment the crystallization of cholesterol. Analysis of different geographical regions GS could be an important stride to understand the etiology of GS diseases.
Related Link: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0166351&type=printable
Citation statistics:
被引频次[WOS]:4   [查看WOS记录]     [查看WOS中相关记录]
Document Type: 期刊论文
Identifier: http://119.78.100.158/handle/2HF3EXSE/23446
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
journal.pone.0166351.PDF(3049KB)期刊论文作者接受稿开放获取View Download

Affiliation: Centre of Biomedical Research, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) - Campus, Lucknow, India;Department of Biosciences, Integral University, Kursi road, Lucknow, India;Centre of Biomedical Research, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) - Campus, Lucknow, India;Department of Biochemistry & BiophysicsUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America;Centre of Biomedical Research, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) - Campus, Lucknow, India;Department of Surgical Gastroenterology, Asian Institute of Gastroenterology, Somajiguda, Hyderabad, Andhra Pradesh, India;Department of Surgery, Zayad Military Hospital, Abu Dhabi, UAE;Department of Surgical Gastroenterology, SGPGIMS, Raibarelly Road Lucknow, Uttar Pradesh, India;Department of Surgical Gastroenterology, Asian Institute of Gastroenterology, Somajiguda, Hyderabad, Andhra Pradesh, India;Department of Biosciences, Integral University, Kursi road, Lucknow, India;Department of Surgical Gastroenterology, SGPGIMS, Raibarelly Road Lucknow, Uttar Pradesh, India

Recommended Citation:
Raj Kumar Sharma,Kanchan Sonkar,Neeraj Sinha,et al. Gallstones: A Worldwide Multifaceted Disease and Its Correlations with Gallbladder Carcinoma[J]. PLOS ONE,2016-01-01,11(11)
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Raj Kumar Sharma]'s Articles
[Kanchan Sonkar]'s Articles
[Neeraj Sinha]'s Articles
百度学术
Similar articles in Baidu Scholar
[Raj Kumar Sharma]'s Articles
[Kanchan Sonkar]'s Articles
[Neeraj Sinha]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Raj Kumar Sharma]‘s Articles
[Kanchan Sonkar]‘s Articles
[Neeraj Sinha]‘s Articles
Related Copyright Policies
Null
收藏/分享
文件名: journal.pone.0166351.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.