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DOI:	10.1371/journal.pone.0149216
论文题名:	Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds
作者:	Denis V. Axenov-Gibanov; Irina V. Voytsekhovskaya; Bogdan T. Tokovenko; Eugeniy S. Protasov; Stanislav V. Gamaiunov; Yuriy V. Rebets; Andriy N. Luzhetskyy; Maxim A. Timofeyev
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2016
发表日期:	2016-2-22
卷:	11, 期:2
语种:	英语
英文关键词:	Streptomyces ; Actinobacteria ; Caves ; Nocardia ; Lakes ; Candida albicans ; Surface water ; Antibiotics
英文摘要:	Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0149216&type=printable
Citation statistics:
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/25214
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0149216.PDF（409KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Irkutsk State University, Institute of Biology, Irkutsk, Russia;Irkutsk State University, Institute of Biology, Irkutsk, Russia;Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany;Irkutsk State University, Institute of Biology, Irkutsk, Russia;Irkutsk State University, Institute of Biology, Irkutsk, Russia;Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany;Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany;Universität des Saarlandes–Pharmazeutische Biotechnologie, Saarbrucken, Germany;Irkutsk State University, Institute of Biology, Irkutsk, Russia

Recommended Citation:

Denis V. Axenov-Gibanov,Irina V. Voytsekhovskaya,Bogdan T. Tokovenko,et al. Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds[J]. PLOS ONE,2016-01-01,11(2)

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