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DOI: 10.1371/journal.pone.0171481
Title:
HIV-1 molecular epidemiology among newly diagnosed HIV-1 individuals in Hebei, a low HIV prevalence province in China
Author: Xinli Lu; Xianjiang Kang; Yongjian Liu; Ze Cui; Wei Guo; Cuiying Zhao; Yan Li; Suliang Chen; Jingyun Li; Yuqi Zhang; Hongru Zhao
Source Publication: PLOS ONE
ISSN: 1932-6203
Indexed By: SCI-E
Publishing Year: 2017
Date Published: 2017-2-8
Volume: 12, Issue:2
Language: 英语
Keyword: HIV-1 ; Men who have sex with men ; Heterosexuals ; Han Chinese ; Phylogeography ; China ; Sequence databases ; HIV epidemiology
Subject in Chinese: 人口
Subject: POPULATION
English Abstract: New human immunodeficiency virus type 1 (HIV-1) diagnoses are increasing rapidly in Hebei. The aim of this study presents the most extensive HIV-1 molecular epidemiology investigation in Hebei province in China thus far. We have carried out the most extensive systematic cross-sectional study based on newly diagnosed HIV-1 positive individuals in 2013, and characterized the molecular epidemiology of HIV-1 based on full length gag-partial pol gene sequences in the whole of Hebei. Nine HIV-1 genotypes based on full length gag-partial pol gene sequence were identified among 610 newly diagnosed naïve individuals. The four main genotypes were circulating recombinant form (CRF)01_AE (53.4%), CRF07_BC (23.4%), subtype B (15.9%), and unique recombinant forms URFs (4.9%). Within 1 year, three new genotypes (subtype A1, CRF55_01B, CRF65_cpx), unknown before in Hebei, were first found among men who have sex with men (MSM). All nine genotypes were identified in the sexually contracted HIV-1 population. Among 30 URFs, six recombinant patterns were revealed, including CRF01_AE/BC (40.0%), CRF01_AE/B (23.3%), B/C (16.7%), CRF01_AE/C (13.3%), CRF01_AE/B/A2 (3.3%) and CRF01_AE/BC/A2 (3.3%), plus two potential CRFs. This study elucidated the complicated characteristics of HIV-1 molecular epidemiology in a low HIV-1 prevalence northern province of China and revealed the high level of HIV-1 genetic diversity. All nine HIV-1 genotypes circulating in Hebei have spread out of their initial risk groups into the general population through sexual contact, especially through MSM. This highlights the urgency of HIV prevention and control in China.
Related Link: http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171481&type=printable
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被引频次[WOS]:10   [查看WOS记录]     [查看WOS中相关记录]
Document Type: 期刊论文
Identifier: http://119.78.100.177/globalchange/handle/2HF3EXSE/26008
Appears in Collections:过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响

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Affiliation: College of Life Science, Hebei University, Baoding, Hebei, China;Hebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China;College of Life Science, Hebei University, Baoding, Hebei, China;Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;Hebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China;NO. 201 hospital of the People’s Liberation Army of China, Liaoyang, Liaoning, China;Hebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China;Hebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China;Hebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China;Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China;Hebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China;Hebei Provincial Center for Disease Control and Prevention, Shjiazhuang, Hebei, China

Recommended Citation:
Xinli Lu,Xianjiang Kang,Yongjian Liu,et al. HIV-1 molecular epidemiology among newly diagnosed HIV-1 individuals in Hebei, a low HIV prevalence province in China[J]. PLOS ONE,2017-01-01,12(2)
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