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DOI:	10.1371/journal.pone.0169491
论文题名:	Norovirus and Sapovirus Epidemiology and Strain Characteristics among Navajo and Apache Infants
作者:	Lindsay R. Grant; Katherine L. O’Brien; Robert C. Weatherholtz; Raymond Reid; Novalene Goklish; Mathuram Santosham; Umesh Parashar; Jan Vinjé
刊名:	PLOS ONE
ISSN:	1932-6203
出版年:	2017
发表日期:	2017-1-3
卷:	12, 期:1
语种:	英语
英文关键词:	Norovirus ; Sapovirus ; Infants ; Phylogeography ; Reverse transcriptase-polymerase chain reaction ; Rotavirus ; Case-control studies ; Vaccines
英文摘要:	Norovirus and sapovirus are important causes of acute gastroenteritis (AGE) among American Indian infants. We investigated the prevalence and molecular epidemiology of norovirus and sapovirus in American Indian infants who have historically experienced a high burden of AGE compared to other US populations. Stool samples were collected from 241 children with AGE (cases) and from 343 infants without AGE (controls) ≤9 months of age from 2002–2004. Cases experienced forceful vomiting and/or 3 or more watery or looser-than-normal stools in 24 hours. Stools were tested by real-time RT-PCR for norovirus GI, GII and GIV and sapovirus GI, GII, GIV and GV. Positive samples were genotyped after sequencing conventional RT-PCR products. Norovirus was identified in 76 (31.5%) of the cases and 70 (20.4%) of the controls (p<0.001). GII.3 and GII.4 Farmington Hills were the most frequently identified genotypes in 14.5% and 30.3% of cases and 17.1% and 27.1% of controls, respectively. Sapovirus GI and GII genotypes were identified in 8 (3.3%) of cases and 8 (2.3%) of controls and a single GIV virus was detected in a control. The same norovirus and sapovirus genotypes were circulating in the general U.S. population in the same time period. The high detection rate of norovirus in healthy controls suggests significant asymptomatic transmission in young infants in these communities.
URL:	http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169491&type=printable
Citation statistics:	被引频次[WOS]:11 [查看WOS记录] [查看WOS中相关记录]
资源类型:	期刊论文
标识符:	http://119.78.100.158/handle/2HF3EXSE/26016
Appears in Collections:	过去全球变化的重建影响、适应和脆弱性科学计划与规划气候变化与战略全球变化的国际研究计划气候减缓与适应气候变化事实与影响

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journal.pone.0169491.pdf（471KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	View Download

作者单位:

Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America;National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America;National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Recommended Citation:

Lindsay R. Grant,Katherine L. O’Brien,Robert C. Weatherholtz,et al. Norovirus and Sapovirus Epidemiology and Strain Characteristics among Navajo and Apache Infants[J]. PLOS ONE,2017-01-01,12(1)

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