| 报告题名: | Evaluation of the combined toxicity assessment and cumulative risk assessment of ecologically relevant mixtures of plant protection Products (PPPs) under Norwegian conditions |
| 作者: | Tollefsen, Knut Erik; Bæk, Kine; Almeida, Ana; Haug, Linn Anette; Norli, Hans; Odenmarck, Sven; Stenrød, Marianne
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| 出版者: | Norsk institutt for vannforskning
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| 出版年: | 2016
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| 发表日期: | 2016
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| 国家: | 挪威
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| 语种: | 英语
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| 英文关键词: | VDP::Matematikk og naturvitenskap: 400
; VDP::Mathematics and natural scienses: 400
; Kombinerte effekter / Combined effects
; Kumulativ risikovurdering / Cumulative risk assessment
; Plantevernmidler / Plant protection products
; Regulatorisk godkjenning / Regulatory approval
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| 中文主题词: | 地表水
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| 主题词: | SURFACE WATER
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| 英文摘要: | This project evaluated whether the principles of combined toxicity assessment (CTA) and cumulative risk assessment
(CRA) can be used to predict the toxicity of ecologically-relevant mixtures of plant protection products (PPPs) in
surface waters receiving run-off from Norwegian agricultural areas. A combination of testing solid phase extracts
(SPE), whole surface water and a synthetic mixture in an algal bioassay and predicting combined toxicity using CTA
models were conducted on selected samples from the Heia catchment (Råde, Norway). The results demonstrated that
designing and testing synthetic mixtures on the basis of measured concentrations of PPPs was the best method for the
accurate determination of combined toxicity due to confounding factors introduced by whole water and SPE testing.
Combined toxicity models based on Concentration Addition (CA) successfully predicted the toxicity of the complex
synthetic mixture and verified that a mixture of PPPs acted in an additive manner. Tiered assessment of the cumulative
risk of active PPP substances and PPP formulations proposed by the European Food Safety Authority (EFSA) were
considered applicable also for the CRA of complex environmental mixtures and could potentially aid the identification of relevant mixtures, risk drivers and susceptible species as input to the assessment and approval of PPPs. |
| URL: | https://brage.bibsys.no/xmlui/bitstream/handle/11250/2391803/7030-2016_200dpi.pdf?sequence=3&isAllowed=y
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| 资源类型: | 研究报告
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/29127
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| Appears in Collections: | 过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响
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| 7030-2016_200dpi.pdf（2829KB） | 研究报告 | -- | 开放获取 | | View
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| Recommended Citation: | |
Tollefsen, Knut Erik,Bæk, Kine,Almeida, Ana,et al. Evaluation of the combined toxicity assessment and cumulative risk assessment of ecologically relevant mixtures of plant protection Products (PPPs) under Norwegian conditions. 2016-01-01.
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