| DOI: | 10.2172/985921
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| 报告号: | LBNL-3744E-Poster
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| 报告题名: | Conservation of Modules but not Phenotype in Bacterial Response to Environmental Stress |
| 作者: | Timberlake, Sonia; Joachimiak, Marcin; Joyner, Dominique; Chakraborty, Romy; Baumohl, Jason; Dehal, Paramvir; Arkin, Adam; Hazen, Terry; Alm, Eric
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| 出版年: | 2010
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| 发表日期: | 2010-05-17
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| 国家: | 美国
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| 语种: | 英语
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| 英文关键词: | transcriptional response
; general stress response
; transcriptional modules
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| 中文主题词: | 保护
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| 主题词: | CONSERVATION
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| 英文摘要: | Microbes live in changing environments and change their phenotype via gene regulation in response. Although this transcriptional response is important for fitness, very little is known about how it evolves in microbes. We started by asking a number of high-level questions about the evolution of transcriptional phenotype: (1) To what extent is transcriptional response conserved, i.e. do conserved genes respond similarly to the same condition; (2) To what extent are transcriptional modules conserved; and (3) Does there exist a general stress response to a variety of stressors? To illuminate these questions, we analyzed more than 500 microarray experiments across the bacterial domain. We looked for conservation of transcriptional regulation both in close sister species and vastly divergent clades. In addition, we produced and analyzed an extensive in-house compendium of environmental stress data in three metal-reducing bacteria. |
| URL: | http://www.osti.gov/scitech/servlets/purl/985921
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| Citation statistics: |
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| 资源类型: | 研究报告
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/39799
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| Appears in Collections: | 过去全球变化的重建
影响、适应和脆弱性
科学计划与规划
气候变化与战略
全球变化的国际研究计划
气候减缓与适应
气候变化事实与影响
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| 985921.pdf（1235KB） | 研究报告 | -- | 开放获取 | | View
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| Recommended Citation: | |
Timberlake, Sonia,Joachimiak, Marcin,Joyner, Dominique,et al. Conservation of Modules but not Phenotype in Bacterial Response to Environmental Stress. 2010-01-01.
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